ul_4185----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name Abl1( Description: v-abl Abelson murine leukemia oncogene 1. )
Synonyms AI325092; Abl; E430008G22Rik; MGC117749; c-Abl
GO annotations GO_component: cytoplasm; nucleus
GO_function:ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity
GO_process: intracellular signaling cascade; peptidyl-tyrosine phosphorylation; protein amino acid phosphorylation; regulation of progression through cell cycle
RefSeq accession NP_033724
SwissProt accession
Sequence:(RefSeq accession:NP_033724; substrate region highlighted if known)
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MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN
SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS
DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA MEYLEKKNFI
HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS
DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP
SDRPSFAEIH QAFETMFQES SISDEVEKEL GKRGTRGGAG SMLQAPELPT KTRTCRRAAE
QKDAPDTPEL LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPRDRKTNLF
SALIKKKKKM APTPPKRSSS FREMDGQPDR RGASEDDSRE LCNGPPALTS DAAEPTKSPK
ASNGAGVPNG AFREPGNSGF RSPHMWKKSS TLTGSRLAAA EEESGMSSSK RFLRSCSASC
MPHGARDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAM
PPPRLVKKNE EAAEEGFKDT ESSPGSSPPS LTPKLLRRQV TASPSSGLSH KEEATKGSAS
GMGTPATAEP APPSNKVGLS KASSEEMRVR RHKHSSESPG RDKGRLAKLK PAPPPPPACT
GKAGKPAQSP SQEAGEAGGP TKTKCTSLAM DAVNTDPTKA GPPGEGLRKP VPPSVPKPQS
TAKPPGTPTS PVSTPSTAPA PSPLAGGQQP SSAAFIPLIS TRVSLRKTRQ PPERIASGTI
TKGVVLDSTE ALCLAISRNS EQMASHSAVL EAGKNLYTFC VSYVDSIQQM RNKFAFREAI
NKLESNLREL QICPATASSG PAATQDFSKL LSSVKEISDI VRR
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
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