ul_4194----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name DMD( Description: dystrophin. )
Synonyms
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_990630
SwissProt accession
Sequence:(RefSeq accession:NP_990630; substrate region highlighted if known)
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MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD GRKLLELLEC
LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS SDIVDGNHKL TLGLIWNIIL
HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ STRNYPQVNV INFTSSWSDG LAFNALLHSH
RPDLFDWNAV ASQQSPVQRL DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF
QVLPQQVTME AIREVEMLPR HSRVTTEEHI QVHHQQHFSQ EITVNIPQRP SPSPKPRFKS
YAYAQTAYVI PPDQKRRQVP PQFLETVEKR TYTTTVMRSE MDLDSYQTAL EEVLTWLLSA
EDALQAQGDI SSDVEVVKEQ FHTHEGFMME LTAHQGRVGN VLQVGSQLLA MGKLSDDEEN
EIQEQMNLLN SRWESLRVAS MEKQSNLHKI LMDLQNQQLA QLADWLTKTE ERTKKIDSEP
LGPDLEDLKR QVEEHKAFQD DLEQEQVKVN SLTHMVVVVD ENSGDKATAA LEEQLQHFGS
RWAAICRWTE DRWVLLQDIL RKWQHFAEEQ CLFDAWLTEK EGSLSKIQTS DFKDENEMLT
SLRKLAILKG DIEMKKQMMS KLKSLSRDLL VAVKNKAVAQ KLESRLENFA QRWDSLVQKL
ESDSKQVSQA VTTTQTSLTQ TTVMETVTMV TTREQILVKH AKEELPPPPP HKKRQLLVDS
EIRKRFDSDT TELHSWMTRS EAVLQSPEFA IYRKEGNLSD LRERVNAIQR EKPEKYRKLQ
DASRSAEALV EQMVNEGLNA DNIRQASEQL KSRWIEFCQL LSERLVWLEY QNSIIDFYSQ
LQRLEQTAIT AENWLKAQPT PATDPATVKI QLEKCKDEII RMSTLQPQIE RLKAQSQALK
EKEQCPVFLD ADLAAFTSHF KQILADMHTR EKQLQTIFDS LPPARYKDTV TTILSWIQQS
ETKVSIPPVA VAEYEIMEQR LGELKALQSS LQEQQKGLKY LNTTVEDLSR KAPAEVSQKY
RSEVELIVGR WKKLSSQLVE HCQKLEDLMT KLQRFQNDTK TLKKWMAEVD VFLKEEWPAL
GDSEALEKQL EQCTALVNDI QTIQPSLNSV NEIGKKMKRE AEPEFASRIA TELKDLNAQW
EHICQQAHAK KAALKGGLDK TVSLRKDLSE MHEWITQAEE EYLERDFEYK TPEELQKAVE
ELKRAKEDAM QKEVKVKLIT DSVNNFIAKA PPAANEALKK ELDVLITSYQ RLCSRLNGKC
KTLEEVWACW HELLSYLDAE NKWLNEVELK LKATENIQGG AEEISESLDS LERLMRHPED
NRNQIRELAQ TLTDGGILDE LINEKLEKFN TRWEELQQEA VRRQKSLEQS IQSAQETDKT
LRLIQESLAA IDKQLTAYTA DRVDAAQVPQ EAQKIQSELT SHEISLEEMK KRNRGKESAK
RVLSQIDVAQ KKLQDVSMKF RLFQKPANFE QRLQECKRIL DEVKLQVPKL ETKSVEQEVV
QSHLDHCMKL YKSLSEVKSE VETVIKTGRQ IVQKQQTENP KELDERLTAL KLQYNELGAK
VTEKKQELEK CLKLSRKLRK EINSLTEWLA ATDVELTKRS AVQGMPSNLD AEIAWGKATR
KEIEKRQVQL KNICDLGENL KTVLKGKESL VEDKLSLLNS NWIAVTSRAE EWLNLLMEYQ
KHMEAFDQKV ANVTTWIYRA EILLDESDKQ KPQQKEETLK RLKAELNDMH PKVDSVRDQA
VDLMTNRGDH CRKVIEPKLS ELNHRFAAIS QRIKSGKPFI PLKELEQFDF DIQKLLEPLE
VEIQQGVNLK EEDFNKDMSE DDESTVKELL QRGDTLQKRI TDERKREEIK IKQQLLQTKH
NALKDLRSQR RKKALEISHQ WYQYKRQADD LMTWLDDIEK KLASLPDHKD EQKLKEIGGE
LEKKKEDLNA VNRQAERLSK DGAAKAVEPT LVQLSKRWRD FESKFAQFRR LNYAQIQTVL
EDTTFVMTES MTVETTYVPS TYLAEILQLL QALSEVEERL NSPVLQAKDC EDLLKQEECL
KNIKDCLGRL QGHIDIIHSK KTPALQSATP RETANIQDKL TQLNSQWEKV NKMYRDRQAR
FDKSKEKWRL FHCEMKSFNE WLTETEEKLS RAQIEAGDVG HVKTKQFLQE LQDGIGRQQT
VVKTLNVTGE EIIEQSSAAD ANVLKEQLGN LNTRWQEICR QLVEKRKRIE EEKNILSEFQ
EDLNKLILWL EETENVIAIP LEPGNEDQLR DCLGKVKLRV EELLPHKGIL KRLNETGGTT
LGSASLNPER KHKLESTLKE ASRRLLKVSR DLPEKQKEIE ILLKDFIELN QQINQLTLWI
TPVKNQLELY NQVGQPGAFD IKETEAAVQA KQPNVEEVLS KGCHLYKEKP ATHPVKKKLE
DLNADWKAIN HLILQLKEKP TFGEPALTSP GVLTSGQTVA VDTQARVTKE TTSFTPEMPS
SVLLEVPALA DFNKAWAELT DWLSRLDREI KAQRVTVGDL DDINDMIIKQ KANMQDLEQR
RPQLDELITA AQNLKNKTSN QEARTIITDR IEKIQSQWDD VHGYLQNRRQ QLHEMQKDST
QWLEAKQEAE QVLEQAKAKL ESWKEISYTV EALKKQNSEL KQFSKEIRQW QMNIEGVNDV
ALKPVRDYSA DDTRKVELMT DNINATWATI NKRVSEREAA LESALLMLQE FYLDLEKFLA
WLTEAETTAN VLQDATHKEK TLEDPQMVRE LMKQWQDLQA EIDAHTDIFH NLDENGQKIL
RSLEGSEDAV LLQRRLDNMN FRWSELRKKS LNIRSHLEAS TDQWKRLHLS LQELLAWLQL
KEDELKQQAP IGGDIPTVQK QNDVHRTFKR ELKTKEPVIM NALETVRLFL ADQPVEGLEK
VYPEPRDLSP EERAQNVTKV LRRQADDVRT EWDKLNLRSA DWQKKIDDAL ERLQGLQEAM
DELDLKLRQA EAFKGSWQPV GDLLIDSLQD HLEKVKVYRA EMVPLKEKVH QVNELAHRFA
PPDIQLSPYT LSCLEDLNTR WKVLQVAIDE RIRQLHEAHR DFGPTSQHFL TTSVQGPWER
AISPNKVPYY INHETQTTCW DHPKMTELYQ SLADLNNVRF SAYRTAMKLR RLQKALCLDL
LNLSAACDAL DQHNLKQNDQ PMDILQIINC LTTIYDRLEQ EHNNLVNVPL CVDMCLNWLL
NVYDTGRTGR IRVLSFKTGV VSLCKAHLED KYRYLFKQVA SSTGFCDQRR LGLLLHDSIQ
IPRQLGEVAS FGGSNIEPSV RSCFQFANNK PEIEAALFLD WMRLEPQSMV WLPVLHRVAA
AETAKHQAKC NICKECPIIG FRYRSLKHFN YDICQSCFFS GRVAKGHKMH YPMVEYCTPT
TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG YLPVQTVLEG DNMETPVTLI NFWPVDSALA
EMENSNGSYL NDSISPNESI DDEHLLIQHY CQSLNQESPL SQPRSPAQIL ISLESEERGE
LERILADLEE ENRNLQAEYD RLKQQHDHKG LSPLPSPPEM MPVSPQSPRD AELIAEAKLL
RQHKGRLEAR MQILEDHNKQ LESQLHRLRQ LLEQPQADAK VNGTTLSSPS TSLQRSDSSQ
PMLLRVVGSQ TSETMGEDDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNA PGKPVREATM
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
End of Record Details