ul_433----
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PPBD protein
Gene name YWHAE( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide. )
Synonyms 14-3-3E; FLJ45465; KCIP-1; MDCR; MDS
GO annotations GO_component:
GO_function:enzyme binding [PMID 10788521]; protein domain specific binding
GO_process:
RefSeq accession NP_006752
SwissProt accession P62258
Substrate protein
Gene name MARK3( Description: MAP/microtubule affinity-regulating kinase 3. )
Synonyms CTAK1; KP78; PAR1A
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein binding [PMID 16169070]; protein serine/threonine kinase activity; transferase activity
GO_process: protein amino acid phosphorylation
RefSeq accession NP_002367
SwissProt accession P62258
GO Pathway:
GO:0006605     protein targeting
Sequence:(RefSeq accession:NP_002367; substrate region highlighted if known)
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MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVF SSQKQRRYSD
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS
THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG
STNLFSKLTS KLTRSRNVSA EQKDENKEAK PRSLRFTWSM KTTSSMDPGD MMREIRKVLD
ANNCDYEQRE RFLLFCVHGD GHAENLVQWE MEVCKLPRLS LNGVRFKRIS GTSIAFKNIA
SKIANELKL
Records:
Category Evidence Reference
A Mutagenesis Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR., Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation., [16968750]
End of Record Details