ul_4425----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name TEC( Description: tec protein tyrosine kinase. )
Synonyms MGC126760; MGC126762; PSCTK4
GO annotations GO_component:
GO_function:ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity [PMID 7934162]; nucleotide binding; transferase activity; zinc ion binding
GO_process: protein amino acid phosphorylation [PMID 7934162]; protein kinase cascade [PMID 7934162]
RefSeq accession NP_003206
SwissProt accession P42680
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_003206; substrate region highlighted if known)
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MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK
CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY
HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS
EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN
NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY
HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY
EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL
THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL
ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYFLDDQYT SSSGAKFPVK WCPPEVFNYS
RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR
CWQEKPEGRP SFEDLLRTID ELVECEETFG R
Records:
Category Evidence Reference
A Inference Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T., Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK, [9178903]
End of Record Details