ul_4432----
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PPBD protein
Gene name PIK3R1
Synonyms PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852664
SwissProt accession P27986
Substrate protein
Gene name IRS-3( Description: insulin receptor substrate 3. )
Synonyms
GO annotations GO_component:
GO_function:insulin receptor binding
GO_process:
RefSeq accession NP_114463
SwissProt accession
GO Pathway:
GO:0005158     insulin receptor binding
Sequence:(RefSeq accession:NP_114463; substrate region highlighted if known)
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MKPAGTGPTV SSGGESTDVS LGPPFPWPCP PDVRLCGHLR KQKSQRRRFF VLRADPPRLE
CYESEKKFLA SGCRPPRPRR TVSLEGACTI SKRADARQRH LIVIYTSDSS LGVAAASEAE
QQTWYSALLE VRATAAAAAA TAMGFSPQEA PESWIFAPFQ DVWPVTLRSK GLGRAPGLSS
GSYRLCLGSG ALSLLRKPGS KGSRDSRATP PPVLRLSLLS VRRCGHADSF FFLELGRSAP
IGPGELWLQA PDAVVAQSIH ETVLAAMKRL GSSAASGKAE APLGDSPKGA SAVPAPAPYE
IPALALAAQA RSPGERAKQD YVNPLERMGS APSYRGPDLG GDYIAMGMRN DYVHMGGKAA
EYMWMAPPGL PPPTPPRVDP RKEPEDCEST EYMPMNRFLP GPLYYEFKAR EPEHGHSSAQ
CSIRDRWRPM VAQPRSSQGS ELSGDYMYIP DYPSARLGSL DSCLNYVDLD LVPPLEVPGA
APGNSPHSYA SIKF
Records:
Category Evidence Reference
A Inference Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF., The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells, [9204876]
End of Record Details