ul_4504----
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PPBD protein
Gene name PIK3R1
Synonyms PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852664
SwissProt accession P27986
Substrate protein
Gene name KIR2DL1( Description: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1. )
Synonyms CD158A; CD158a antigen; KIR-K64; KIR221; MHC class I NK cell receptor; NKAT; NKAT-1; NKAT1; Natural killer-associated transcript 1; p58 NK receptor; p58 natural killer cell receptor clones CL-42/47.11; p58.1; p58.1 MHC class-I-specific NK receptor
GO annotations GO_component: integral to plasma membrane [PMID 7749980] [PMID 10424431]; membrane
GO_function:HLA-C specific inhibitory MHC class I receptor activity [PMID 10424431]; receptor activity
GO_process: immune response [PMID 10424431]
RefSeq accession NP_055033
SwissProt accession P43626
Sequence:(RefSeq accession:NP_055033; substrate region highlighted if known)
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MSLLFVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVMFEHFLL
HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC YGSVTHSPYQ VSAPSDPLDI
VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNGT
FQADFPLGPA THGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN
PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP
Records:
Category Evidence Reference
A Mutagenesis Marti F, Xu CW, Selvakumar A, Brent R, Dupont B, King PD., LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase, [9751747]
End of Record Details