ul_453----
Record details: Hide
PPBD protein
Gene name YWHAG( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide. )
Synonyms 14-3-3GAMMA; KCIP-1; Protein kinase C inhibitor protein 1
GO annotations GO_component: cytoplasm
GO_function:actin binding; insulin-like growth factor receptor binding [PMID 12482592]; protein domain specific binding; protein homodimerization activity; protein kinase C binding [PMID 10433554]; protein kinase C inhibitor activity [PMID 10433554]
GO_process: cytoskeleton organization and biogenesis; negative regulation of apoptosis; negative regulation of protein kinase activity [PMID 10433554]; regulation of mitosis; regulation of neuron differentiation [PMID 11824616]; regulation of signal transduction [PMID 10433554] [PMID 10486217]; regulation of synaptic plasticity [PMID 11824616]
RefSeq accession NP_036611
SwissProt accession P61981
Substrate protein
Gene name CDC25C
Synonyms Dual specificity phosphatase Cdc25C; EC 3.1.3.48
GO annotations GO_component: intracellular; nucleus
GO_function:hydrolase activity; protein tyrosine phosphatase activity [PMID 11078813]
GO_process: cell cycle; cell division; cell proliferation [PMID 11139144]; protein amino acid dephosphorylation; regulation of cyclin-dependent protein kinase activity [PMID 11139144]; regulation of mitosis [PMID 1828290]; traversing start control point of mitotic cell cycle [PMID 2195549]
RefSeq accession NP_001781
SwissProt accession P30307
GO Pathway:
GO:0007049     cell cycle
Sequence:(RefSeq accession:NP_001781; substrate region highlighted if known)
1
61
121
181
241
301
361
421
MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
SILSGGTPKC CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP
Records:
Category Evidence Reference
A Mutagenesis Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H., Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis., [9278512]
End of Record Details