ul_4538----
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PPBD protein
Gene name PIK3R1
Synonyms PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852664
SwissProt accession P27986
Substrate protein
Gene name Inr( Description: Insulin-like receptor. )
Synonyms CG18402; DIHR; DILR; DIR; DIRH; DIRbeta; DInR; INR; IR; InsR; dInsR; er10; insulin/insulin-like growth factor receptor; l(3)05545
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_524436
SwissProt accession
Sequence:(RefSeq accession:NP_524436; substrate region highlighted if known)
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MFNMPRGVTK SKSKRGKIKM ENDMAAAATT TACTLGHICV LCRQEMLLDT CCCRQAVEAV
DSPASSEEAY SSSNSSSCQA SSEISAEEVW FLSHDDIVLC RRPKFDEVET TGKKRDVKCS
GHQCSNECDD GSTKNNRQQR ENFNIFSNCH NILRTLQSLL LLMFNCGIFN KRRRRQHQQQ
HHHHYQHHHQ QHHQQHHQRQ QANVSYTKFL LLLQTLAAAT TRLSLSPKNY KQQQQLQHNQ
QLPRATPQQK QQEKDRHKCF HYKHNYSYSP GISLLLFILL ANTLAIQAVV LPAHQQHLLH
NDIADGLDKT ALSVSGTQSR WTRSESNPTM RLSQNVKPCK SMDIRNMVSH FNQLENCTVI
EGFLLIDLIN DASPLNRSFP KLTEVTDYII IYRVTGLHSL SKIFPNLSVI RGNKLFDGYA
LVVYSNFDLM DLGLHKLRSI TRGGVRIEKN HKLCYDRTID WLEILAENET QLVVLTENGK
EKECRLSKCP GEIRIEEGHD TTAIEGELNA SCQLHNNRRL CWNSKLCQTK CPEKCRNNCI
DEHTCCSQDC LGGCVIDKNG NESCISCRNV SFNNICMDSC PKGYYQFDSR CVTANECITL
TKFETNSVYS GIPYNGQCIT HCPTGYQKSE NKRMCEPCPG GKCDKECSSG LIDSLERARE
FHGCTIITGT EPLTISIKRE SGAHVMDELK YGLAAVHKIQ SSLMVHLTYG LKSLKFFQSL
TEISGDPPMD ADKYALYVLD NRDLDELWGP NQTVFIRKGG VFFHFNPKLC VSTINQLLPM
LASKPKFFEK SDVGADSNGN RGSCGTAVLN VTLQSVGANS AMLNVTTKVE IGEPQKPSNA
TIVFKDPRAF IGFVFYHMID PYGNSTKSSD DPCDDRWKVS SPEKSGVMVL SNLIPYTNYS
YYVRTMAISS ELTNAESDVK NFRTNPGRPS KVTEVVATAI SDSKINVTWS YLDKPYGVLT
RYFIKAKLIN RPTRNNNRDY CTEPLVKAME NDLPATTPTK KISDPLAGDC KCVEGSKKTS
SQEYDDRKVQ AGMEFENALQ NFIFVPNIRK SKNGSSDKSD GAEGAALDSN AIPNGGATNP
SRRRRDVALE PELDDVEGSV LLRHVRSITD DTDAFFEKDD ENTYKDEEDL SSNKQFYEVF
AKELPPNQTH FVFEKLRHFT RYAIFVVACR EEIPSEKLRD TSFKKSLCSD YDTVFQTTKR
KKFADIVMDL KVDLEHANNT ESPVRVRWTP PVDPNGEIVT YEVAYKLQKP DQVEEKKCIP
AADFNQTAGY LIKLNEGLYS FRVRANSIAG YGDFTEVEHI KVEPPPSYAK VFFWLLGIGL
AFLIVSLFGY VCYLHKRKVP SNDLHMNTEV NPFYASMQYI PDDWEVLREN IIQLAPLGQG
SFGMVYEGIL KSFPPNGVDR ECAIKTVNEN ATDRERTNFL SEASVMKEFD TYHVVRLLGV
CSRGQPALVV MELMKKGDLK SYLRAHRPEE RDEAMMTYLN RIGVTGNVQP PTYGRIYQMA
IEIADGMAYL AAKKFVHRDL AARNCMVADD LTVKIGDFGM TRDIYETDYY RKGTKGLLPV
RWMPPESLRD GVYSSASDVF SFGVVLWEMA TLAAQPYQGL SNEQVLRYVI DGGVMERPEN
CPDFLHKLMQ RCWHHRSSAR PSFLDIIAYL EPQCPNSQFK EVSFYHSEAG LQHREKERKE
RNQLDAFAAV PLDQDLQDRE QQEDATTPLR MGDYQQNSSL DQPPESPIAM VDDQGSHLPF
SLPSGFIASS TPDGQTVMAT AFQNIPAAQG DISATYVVPD ADALDGDRGY EIYDPSPKCA
ELPTSRSGST GGGKLSGEQH LLPRKGRQPT IMSSSMPDDV IGGSSLQPST ASAGSSNASS
HTGRPSLKKT VADSVRNKAN FINRHLFNHK RTGSNASHKS NASNAPSTSS NTNLTSHPVA
MGNLGTIESG GSGSAGSYTG TPRFYTPSAT PGGGSGMAIS DNPNYRLLDE SIASEQATIL
TTSSPNPNYE MMHPPTSLVS TNPNYMPMNE TPVQMAGVTI SHNPNYQPMQ APLNARQSQS
SSDEDNEQEE DDEDEDDDVD DEHVEHIKME RMPLSRPRQR ALPSKTQPPR SRSVSQTRKS
PTNPNSGIGA TGAGNRSNLL KENWLRPAST PRPPPPNGFI GREA
Records:
Category Evidence Reference
A Inference Marin-Hincapie M, Garofalo RS., The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survival, [10455177]
End of Record Details