ul_4563----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name Tyro3( Description: TYRO3 protein tyrosine kinase 3. )
Synonyms Brt
GO annotations GO_component: extracellular space; integral to membrane; integral to plasma membrane; membrane
GO_function:nucleotide binding; phosphoinositide 3-kinase binding; protein binding; protein serine/threonine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
GO_process: cell adhesion; protein amino acid phosphorylation; signal transduction
RefSeq accession NP_058788
SwissProt accession
Sequence:(RefSeq accession:NP_058788; substrate region highlighted if known)
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MALRRSMGRP GLRPLLLAGL ASLLLPGSAA AGLKLMGAPV KMTVSQGQPV KLNCSVEGMD
DPDIHWMKDG AVVQNASQVS ISISEQNWIG LLSLKSAERS DAGLYWCQVK DGEETKISQS
VWLTVEGVPF FTVEPKDLAV PPNVPFQLSC EAVGPPEPVT IFWWRGPTKV GGPASSPSVL
NVTGVTQRTE FSCEAHNIKG LATSRPAIIR LQAPPAAPFN ITVTTISSSN ASVAWVPGAD
GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG
DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD
ELMVEGTTAN LTDWDPQKDL VLRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWV
PVVLGVLTAL ITAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA RSFNRERPER
IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE DGSFVKVAVK
MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM VILPFMKHGD
LHAFLLASRI GENPFNLPLQ TLVRFMVDIA CGMEYLSSRN FIHRDLAARN CMLAEDMTVC
VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VHSDVWAFGV TMWEIMTRGQ
TPYAGIENAE IYNYLISGNR LKQPPECMEE VYDLMYQCWS ADPKQRPSFT CLRMELENIL
GHLSVLSTSQ DPLYINIERA GQPAENGSPE LPCGEQSSSE AGDGSGMGAI GGIPSDCRYI
FSPGGLAESP GQLEQQPESP LNENQRLLLL QQGLLPHSSC
Records:
Category Evidence Reference
A Inference Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W., Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway, [10627473]
End of Record Details