ul_4568----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name TRAT1( Description: T cell receptor associated transmembrane adaptor 1. )
Synonyms HSPC062; T-cell receptor-interacting molecule; TCRIM; TRIM; pp29/30
GO annotations GO_component: integral to membrane; plasma membrane [PMID 11390434]; T cell receptor complex [PMID 11390434]
GO_function:
GO_process: immune response; negative regulation of receptor recycling [PMID 11390434]; negative regulation of transport [PMID 11390434]; positive regulation of calcium-mediated signaling [PMID 11390434]; positive regulation of T cell receptor signaling pathway [PMID 11390434]
RefSeq accession NP_057472
SwissProt accession Q6PIZ9
Sequence:(RefSeq accession:NP_057472; substrate region highlighted if known)
1
61
121
181
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT
PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK
RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA
KREPIN
Records:
Category Evidence Reference
A Inference Zhang W, Samelson LE., The role of membrane-associated adaptors in T cell receptor signalling, [10723796]
End of Record Details