ul_4614----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name Erbb2( Description: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). )
Synonyms
GO annotations GO_component: apical plasma membrane; cytoplasm; integral to membrane; membrane; plasma membrane
GO_function:epidermal growth factor receptor activity; ErbB-3 class receptor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
GO_process: cell proliferation; central nervous system development; glial cell differentiation; heart development; mammary gland development; myelination; nervous system development; peripheral nervous system development; phosphoinositide-mediated signaling; positive regulation of epithelial cell proliferation; positive regulation of MAPK activity; protein amino acid phosphorylation; regulation of angiogenesis; regulation of cell differentiation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_058699
SwissProt accession
GO Pathway:
GO:0014068     positive regulation of phosphoinositide 3-kinase cascade
Sequence:(RefSeq accession:NP_058699; substrate region highlighted if known)
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MIIMELAAWC RWGFLLALLP PGIAGTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ
GNLELTYVPA NASLSFLQDI QEVQGYMLIA HNQVKRVPLQ RLRIVRGTQL FEDKYALAVL
DNRDPQDNVA ASTPGRTPEG LRELQLRSLT EILKGGVLIR GNPQLCYQDM VLWKDVFRKN
NQLAPVDIDT NRSRACPPCA PACKDNHCWG ESPEDCQILT GTICTSGCAR CKGRLPTDCC
HEQCAAGCTG PKHSDCLACL HFNHSGICEL HCPALVTYNT DTFESMHNPE GRYTFGASCV
TTCPYNYLST EVGSCTLVCP PNNQEVTAED GTQRCEKCSK PCARVCYGLG MEHLRGARAI
TSDNVQEFDG CKKIFGSLAF LPESFDGDPS SGIAPLRPEQ LQVFETLEEI TGYLYISAWP
DSLRDLSVFQ NLRIIRGRIL HDGAYSLTLQ GLGIHSLGLR SLRELGSGLA LIHRNAHLCF
VHTVPWDQLF RNPHQALLHS GNRPEEDCGL EGLVCNSLCA HGHCWGPGPT QCVNCSHFLR
GQECVEECRV WKGLPREYVS DKRCLPCHPE CQPQNSSETC FGSEADQCAA CAHYKDSSSC
VARCPSGVKP DLSYMPIWKY PDEEGICQPC PINCTHSCVD LDERGCPAEQ RASPVTFIIA
TVVGVLLFLI LVVVVGILIK RRRQKIRKYT MRRLLQETEL VEPLTPSGAM PNQAQMRILK
ETELRKVKVL GSGAFGTVYK GIWIPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG
VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVREHRGR LGSQDLLNWC VQIAKGMSYL
EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE YHADGGKVPI KWMALESILR
RRFTHQSDVW SYGVTVWELM TFGAKPYDGI PAREIPDLLE KGERLPQPPI CTIDVYMIMV
KCWMIDSECR PRFRELVSEF SRMARDPQRF VVIQNEDLGP SSPMDSTFYR SLLEDDDMGD
LVDAEEYLVP QQGFFSPDPT PGTGSTAHRR HRSSSTRSGG GELTLGLEPS EEGPPRSPLA
PSEGAGSDVF DGDLAMGVTK GLQSLSPHDL SPLQRYSEDP TLPLPPETDG YVAPLACSPQ
PEYVNQSEVQ PQPPLTPEGP LPPVRPAGAT LERPKTLSPG KNGVVKDVFA FGGAVENPEY
LVPREGTASP PHPSPAFSPA FDNLYYWDQN SSEQGPPPSN FEGTPTAENP EYLGLDVPV
Records:
Category Evidence Reference
A Mutagenesis Hellyer NJ, Kim MS, Koland JG., Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor, [11546794]
End of Record Details