ul_4632----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name Tie1( Description: tyrosine kinase receptor 1. )
Synonyms D430008P04Rik; TIE
GO annotations GO_component: membrane
GO_function:ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: negative regulation of angiogenesis; negative regulation of cell migration; plasma membrane fusion; protein amino acid phosphorylation
RefSeq accession NP_035717
SwissProt accession
GO Pathway:
KEGG:04210     KEGG pathway: Apoptosis
Sequence:(RefSeq accession:NP_035717; substrate region highlighted if known)
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MVWWGSSLLL PTLFLASHVG ASVDLTLLAN LRITDPQRFF LTCVSGEAGA GRSSDPPLLL
EKDDRIVRTF PPGQPLYLAR NGSHQVTLRG FSKPSDLVGV FSCVGGAGAR RTRVLYVHNS
PGAHLFPDKV THTVNKGDTA VLSAHVHKEK QTDVIWKNNG SYFNTLDWQE ADDGRFQLQL
QNVQPPSSGI YSATYLEASP LGSAFFRLIV RGCGAGRWGP GCVKDCPGCL HGGVCHDHDG
ECVCPPGFTG TRCEQACREG RFGQSCQEQC PGTAGCRGLT FCLPDPYGCS CGSGWRGSQC
QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ ILSMATEVEF
NIGTMPRINC AAAGNPFPVR GSMKLRKPDG TMLLSTKVIV EPDRTTAEFE VPSLTLGDSG
FWECRVSTSG GQDSRRFKVN VKVPPVPLTA PRLLAKQSRQ LVVSPLVSFS GDGPISSVRL
HYRPQDSTIA WSAIVVDPSE NVTLMNLKPK TGYNVRVQLS RPGEGGEGGW GPSALMTTDC
PEPLLQPWLE SWHVEGPDRL RVSWSLPSVP LSGDGFLLRL WDGARGQERR ENISFPQART
ALLTGLTPGT HYQLDVRLYH CTLLGPASPP AHVHLPPSGP PAPRHLHAQA LSDSEIQLMW
QHPEAPSGPI SKYIVEIQVA GGSGDPQWMD VDRPEETSII VRGLNASTRY LFRVRASVQG
LGDWSNTVEE ATLGNGLQSE GPVRESRAAE EGLDQQLVLA VVGSVSATCL TILAALLALV
CIRRSCLHRR RTFTYQSGSG EETILQFSSG TLTLTRRPKP QPEPLSYPVL EWEDITFEDL
IGEGNFGQVI RAMIKKDGLK MNAAIKMLKE YASENDHRDF AGELEVLCKL GHHPNIINLL
GACENRGYLY IAIEYAPYGN LLDFLRKSRV LETDPAFARE HGTASTLSSR QLLRFASDAA
NGMQYLSEKQ FIHRDLAARN VLVGENLASK IADFGLSRGE EVYVKKTMGR LPVRWMAIES
LNYSVYTTKS DVWSFGVLLW EIVSLGGTPY CGMTCAELYE KLPQGYRMEQ PRNCDDEVYE
LMRQCWRDRP YERPPFAQIA LQLGRMLEAR KAYVNMSLFE NFTYAGIDAT AEEA
Records:
Category Evidence Reference
A Mutagenesis Kontos CD, Cha EH, York JD, Peters KG., The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis, [11865050]
End of Record Details