ul_4633----
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PPBD protein
Gene name PIK3R1( Description: coilin. )
Synonyms CLN80; PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p80-coilin; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852556
SwissProt accession P27986
Substrate protein
Gene name Tek( Description: endothelial-specific receptor tyrosine kinase. )
Synonyms AA517024; Cd202b; Hyk; Tie2
GO annotations GO_component: membrane
GO_function:ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: cell-cell adhesion; cell-matrix adhesion; protein amino acid phosphorylation; regulation of angiogenesis; regulation of cell migration
RefSeq accession NP_038718
SwissProt accession
Sequence:(RefSeq accession:NP_038718; substrate region highlighted if known)
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MDSLAGLVLC GVSLLLYGVV EGAMDLILIN SLPLVSDAET SLTCIASGWH PHEPITIGRD
FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY FCEGRVRGQA IRIRTMKMRQ
QASFLPATLT MTVDRGDNVN ISFKKVLIKE EDAVIYKNGS FIHSVPRHEV PDILEVHLPH
AQPQDAGVYS ARYIGGNLFT SAFTRLIVRR CEAQKWGPDC SRPCTTCKNN GVCHEDTGEC
ICPPGFMGRT CEKACEPHTF GRTCKERCSG PEGCKSYVFC LPDPYGCSCA TGWRGLQCNE
ACPSGYYGPD CKLRCHCTNE EICDRFQGCL CSQGWQGLQC EKEGRPRMTP QIEDLPDHIE
VNSGKFNPIC KASGWPLPTS EEMTLVKPDG TVLQPNDFNY TDRFSVAIFT VNRVLPPDSG
VWVCSVNTVA GMVEKPFNIS VKVLPEPLHA PNVIDTGHNF AIINISSEPY FGDGPIKSKK
LFYKPVNQAW KYIEVTNEIF TLNYLEPRTD YELCVQLARP GEGGEGHPGP VRRFTTASIG
LPPPRGLSLL PKSQTALNLT WQPIFTNSED EFYVEVERRS LQTTSDQQNI KVPGNLTSVL
LSNLVPREQY TVRARVNTKA QGEWSEELRA WTLSDILPPQ PENIKISNIT DSTAMVSWTI
VDGYSISSII IRYKVQGKNE DQHIDVKIKN ATVTQYQLKG LEPETTYHVD IFAENNIGSS
NPAFSHELRT LPHSPASADL GGGKMLLIAI LGSAGMTCIT VLLAFLIMLQ LKRANVQRRM
AQAFQNVREE PAVQFNSGTL ALNRKAKNNP DPTIYPVLDW NDIKFQDVIG EGNFGQVLKA
RIKKDGLRMD AAIKRMKEYA SKDDHRDFAG ELEVLCKLGH HPNIINLLGA CEHRGYLYLA
IEYAPHGNLL DFLRKSRVLE TDPAFAIANS TASTLSSQQL LHFAADVARG MDYLSQKQFI
HRDLAARNIL VGENYIAKIA DFGLSRGQEV YVKKTMGRLP VRWMAIESLN YSVYTTNSDV
WSYGVLLWEI VSLGGTPYCG MTCAELYEKL PQGYRLEKPL NCDDEVYDLM RQCWREKPYE
RPSFAQILVS LNRMLEERKT YVNTTLYEKF TYAGIDCSAE EAA
Records:
Category Evidence Reference
A Mutagenesis Kontos CD, Cha EH, York JD, Peters KG., The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis, [11865050]
End of Record Details