ul_4682----
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PPBD protein
Gene name PIK3R1
Synonyms PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852664
SwissProt accession P27986
Substrate protein
Gene name WASF3( Description: WAS protein family, member 3. )
Synonyms Brush-1; KIAA0900; Protein WAVE-3; SCAR3; Verprolin homology domain-containing protein 3; WASP-family protein member 3; WAVE3
GO annotations GO_component: actin cytoskeleton
GO_function:actin binding
GO_process: actin filament polymerization [PMID 10381382]; protein complex assembly [PMID 10381382]
RefSeq accession NP_006637
SwissProt accession Q9UPY6
GO Pathway:
GO:0030041     actin filament polymerization
Sequence:(RefSeq accession:NP_006637; substrate region highlighted if known)
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MPLVKRNIEP RHLCRGALPE GITSELECVT NSTLAAIIRQ LSSLSKHAED IFGELFNEAN
NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA FKSSTVQDQQ VVSKNSIPNP
VADIYNQSDK PPPLNILTPY RDDKKDGLKF YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK
EQKRIDGTTR EVKKVRKARN RRQEWNMMAY DKELRPDNRL SQSVYHGASS EGSLSPDTRS
HASDVTDYSY PATPNHSLHP QPVTPSYAAG DVPPHGPASQ AAEHEYRPPS ASARHMALNR
PQQPPPPPPP QAPEGSQASA PMAPADYGML PAQIIEYYNP SGPPPPPPPP VIPSAQTAFV
SPLQMPMQPP FPASASSTHA APPHPPSTGL LVTAPPPPGP PPPPPGPPGP GSSLSSSPMH
GPPVAEAKRQ EPAQPPISDA RSDLLAAIRM GIQLKKVQEQ REQEAKREPV GNDVATILSR
RIAVEYSDSD DDSEFDENDW SD
Records:
Category Evidence Reference
A Inference Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK., WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase, [15826941]
End of Record Details