ul_4683----
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PPBD protein
Gene name PIK3R1
Synonyms PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852664
SwissProt accession P27986
Substrate protein
Gene name Gab2( Description: growth factor receptor bound protein 2-associated protein 2. )
Synonyms AI463667; D130058I17Rik; p97
GO annotations GO_component:
GO_function:protein binding; receptor activity
GO_process: cell migration; integrin-mediated signaling pathway
RefSeq accession NP_034378
SwissProt accession
Sequence:(RefSeq accession:NP_034378; substrate region highlighted if known)
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MSGGGGDDVV CTGWLRKSPP EKKLRRYAWK KRWFILRSGR MSGDPDVLEY YKNEHSKKPL
RIINLNLCEQ VDAGLTFNKK ELQDSFVFDI KTSERTFYLV AETEADMNKW VQSICQICGF
NQAEESTDSL RNLSSASHGP RSSPAEFSSS QHLLRERKSS APSHSSQPTL FTFEPPVSSH
MQPTLSTSAP QEYLYLHQCI SRRTENARSA SFSQGTRQKS DTAVQKLAQS NGHCINGVGG
QVHGFYSLPK PSRHNTEFKD STYDLPRSLA SHGHTKSSLT GSETDNEDVY TFKMPSNTLC
RELGDLLVDN MDVPTTPLSA YQIPRTFTLD KNHNAMTVAT PGDSAIAPPP RPPKPSQAET
SQWGSIQQRP PISENSRSVA ATIPRRNTLP AMDNSRLHRA SSCETYEYPA RGSGESASWS
AEPPGKTAVG RSNSASSDDN YVPMNPGSST LLAMERPGDN SQSVYIPMSP GPHHFDPLGY
PSTALPIHRG PSRGSEIQPP PVNRNLKPDR KAKPTPLDLR NNTVIDELPF KSPVTKSWSR
INSHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT NSPAPKKSTG
SVDYLALDFQ PGSPSPHRKP STSSVTSDEK VDYVQVDKEK TQALQNTMQE WTDVRQSSEP
SKGAKL
Records:
Category Evidence Reference
A Inference Nyga R, Pecquet C, Harir N, Gu H, Dhennin-Duthille I, Regnier A, Gouilleux-Gruart V, Lassoued K, Gouilleux F., Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter, [15833084]
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