ul_4725----
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PPBD protein
Gene name PIK3R1
Synonyms PI3-kinase p85 subunit alpha; PI3K; PtdIns-3-kinase p85-alpha; p85a
GO annotations GO_component: intracellular; phosphoinositide 3-kinase complex; phosphoinositide 3-kinase complex, class IA
GO_function:ErbB-3 class receptor binding [PMID 10572067]; insulin binding [PMID 8440175]; insulin receptor binding [PMID 7537849] [PMID 8276809]; insulin receptor substrate binding; insulin-like growth factor receptor binding [PMID 7541045]; kinase activity; phosphatidylinositol binding; phosphoinositide 3-kinase regulator activity; protein phosphatase binding [PMID 14699157]
GO_process: insulin receptor signaling pathway [PMID 8276809]; insulin-like growth factor receptor signaling pathway [PMID 7541045]; intracellular signaling cascade; phosphoinositide phosphorylation
RefSeq accession NP_852664
SwissProt accession P27986
Substrate protein
Gene name SSTR2( Description: somatostatin receptor 2. )
Synonyms SRIF-1; SS2R
GO annotations GO_component: integral to plasma membrane [PMID 7914078]; plasma membrane [PMID 7914078]
GO_function:PDZ domain binding [PMID 10551867]; protein binding [PMID 10551867]; receptor activity; rhodopsin-like receptor activity; somatostatin receptor activity [PMID 7914078]
GO_process: cell-cell signaling [PMID 1346068]; digestion [PMID 1346068]; G-protein signaling, coupled to cyclic nucleotide second messenger [PMID 7914078]; negative regulation of cell proliferation [PMID 9892014]; response to nutrient [PMID 1346068]; signal transduction
RefSeq accession NP_001041
SwissProt accession P30874
GO Pathway:
GO:0006915     apoptosis
Sequence:(RefSeq accession:NP_001041; substrate region highlighted if known)
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MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY FVVCIIGLCG
NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA MQVALVHWPF GKAICRVVMT
VDGINQFTSI FCLTVMSIDR YLAVVHPIKS AKWRRPRTAK MITMAVWGVS LLVILPIMIY
AGLRSNQWGR SSCTINWPGE SGAWYTGFII YTFILGFLVP LTIICLCYLF IIIKVKSSGI
RVGSSKRKKS EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SMAISPTPAL KGMFDFVVVL
TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL NETTETQRTL
LNGDLQTSI
Records:
Category Evidence Reference
A Mutagenesis Bousquet C, Guillermet-Guibert J, Saint-Laurent N, Archer-Lahlou E, Lopez F, Fanjul M, Ferrand A, Fourmy D, Pichereaux C, Monsarrat B, Pradayrol L, Esteve JP, Susini C., Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway, [16917505]
End of Record Details