ul_473----
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PPBD protein
Gene name YWHAG( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide. )
Synonyms 14-3-3GAMMA; KCIP-1; Protein kinase C inhibitor protein 1
GO annotations GO_component: cytoplasm
GO_function:actin binding; insulin-like growth factor receptor binding [PMID 12482592]; protein domain specific binding; protein homodimerization activity; protein kinase C binding [PMID 10433554]; protein kinase C inhibitor activity [PMID 10433554]
GO_process: cytoskeleton organization and biogenesis; negative regulation of apoptosis; negative regulation of protein kinase activity [PMID 10433554]; regulation of mitosis; regulation of neuron differentiation [PMID 11824616]; regulation of signal transduction [PMID 10433554] [PMID 10486217]; regulation of synaptic plasticity [PMID 11824616]
RefSeq accession NP_036611
SwissProt accession P61981
Substrate protein
Gene name FOXO1A( Description: forkhead box O1. )
Synonyms FKH1; FKHR; FOXO1A
GO annotations GO_component: nucleus
GO_function:sequence-specific DNA binding; transcription factor activity [PMID 7862145] [PMID 10871843]
GO_process: anti-apoptosis [PMID 10871843]; regulation of transcription from RNA polymerase II promoter [PMID 10871843]; regulation of transcription, DNA-dependent; transcription
RefSeq accession NP_002006
SwissProt accession Q12778
Sequence:(RefSeq accession:NP_002006; substrate region highlighted if known)
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MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA NPDAAAGLPS
ASAAAVSADF MSNLSLLEES EDFPQAPGSV AAAVAAAAAA AATGGLCGDF QGPEAGCLHP
APPQPPPPGP LSQHPPVPPA AAGPLAGQPR KSSSSRRNAW GNLSYADLIT KAIESSAEKR
LTLSQIYEWM VKSVPYFKDK GDSNSSAGWK NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN
PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG
SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP
SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN
YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV
DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP
HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS
DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG
Records:
Category Evidence Reference
A Mutagenesis Rena G, Prescott AR, Guo S, Cohen P, Unterman TG., Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting., [11237865]
End of Record Details