ul_4783----
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PPBD protein
Gene name PIK3R3( Description: tumor protein p53 (Li-Fraumeni syndrome). )
Synonyms LFS1; PI3-kinase p85 subunit gamma; PtdIns-3-kinase p85-gamma; TRP53; p53; p55PIK
GO annotations GO_component: phosphoinositide 3-kinase complex
GO_function:kinase activity; phosphatidylinositol 3-kinase activity [PMID 9524259]; phosphoinositide 3-kinase regulator activity; protein binding [PMID 8647200]
GO_process: insulin receptor signaling pathway [PMID 9524259]; intracellular signaling cascade
RefSeq accession NP_003620
SwissProt accession Q92569
Substrate protein
Gene name TEC( Description: tec protein tyrosine kinase. )
Synonyms MGC126760; MGC126762; PSCTK4
GO annotations GO_component:
GO_function:ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity [PMID 7934162]; nucleotide binding; transferase activity; zinc ion binding
GO_process: protein amino acid phosphorylation [PMID 7934162]; protein kinase cascade [PMID 7934162]
RefSeq accession NP_003206
SwissProt accession P42680
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_003206; substrate region highlighted if known)
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MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK
CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY
HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS
EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN
NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY
HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY
EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL
THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL
ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYFLDDQYT SSSGAKFPVK WCPPEVFNYS
RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR
CWQEKPEGRP SFEDLLRTID ELVECEETFG R
Records:
Category Evidence Reference
A Inference Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T., Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK, [9178903]
End of Record Details