ul_4858----
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PPBD protein
Gene name PLCG1
Synonyms EC 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C; Phospholipase C-gamma-1
GO annotations GO_component:
GO_function:calcium ion binding; hydrolase activity; phosphoinositide phospholipase C activity [PMID 2167438]; protein binding [PMID 10873601] [PMID 14722116]; receptor signaling protein activity [PMID 7681365]; signal transducer activity
GO_process: intracellular signaling cascade; lipid catabolism; lipid metabolism
RefSeq accession NP_002651
SwissProt accession P19174
Substrate protein
Gene name LIFR( Description: leukemia inhibitory factor receptor alpha. )
Synonyms CD118; CD118 antigen; LIF receptor; LIF-R; SJS2; STWS; SWS
GO annotations GO_component: integral to plasma membrane [PMID 1915266]; membrane
GO_function:leukemia inhibitory factor receptor activity [PMID 1915266]; receptor activity
GO_process: cell surface receptor linked signal transduction [PMID 1915266]
RefSeq accession NP_002301
SwissProt accession P42702
GO Pathway:
GO:0007166     cell surface receptor linked signal transduction
Sequence:(RefSeq accession:NP_002301; substrate region highlighted if known)
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MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL
QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS
STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE
SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP
VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA
LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ
STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR
NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD
TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK
WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE
ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR
SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI
LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN
PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE
DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS
NGGGWSFTNF FQNKPND
Records:
Category Evidence Reference
A Inference Boulton TG, Stahl N, Yancopoulos GD., Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors, [7512571]
End of Record Details