ul_4860----
Record details: Hide
PPBD protein
Gene name PLCG1
Synonyms EC 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C; Phospholipase C-gamma-1
GO annotations GO_component:
GO_function:calcium ion binding; hydrolase activity; phosphoinositide phospholipase C activity [PMID 2167438]; protein binding [PMID 10873601] [PMID 14722116]; receptor signaling protein activity [PMID 7681365]; signal transducer activity
GO_process: intracellular signaling cascade; lipid catabolism; lipid metabolism
RefSeq accession NP_002651
SwissProt accession P19174
Substrate protein
Gene name MAG( Description: myelin associated glycoprotein. )
Synonyms GMA; S-MAG; SIGLEC-4A; SIGLEC4A
GO annotations GO_component: integral to membrane; membrane
GO_function:protein binding; sugar binding
GO_process: cell adhesion
RefSeq accession NP_002352
SwissProt accession P20916
Sequence:(RefSeq accession:NP_002352; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY
FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSNVSPE LGGKYYFRGD
LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL
GEPAVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP
VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED
GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ SNPDPILTIF
KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ RATAFNLSVE FAPVLLLESH
CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNESEREF VYSERSGLVL TSILTLRGQA
QAPPRVICTA RNLYGAKSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK
NVTESPSFSA GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS
DLGKRPTKDS YTLTEELAEY AEIRVK
Records:
Category Evidence Reference
A Mutagenesis Jaramillo ML, Afar DE, Almazan G, Bell JC., Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules, [7525550]
End of Record Details