ul_4882----
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PPBD protein
Gene name PLCG1
Synonyms EC 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C; Phospholipase C-gamma-1
GO annotations GO_component:
GO_function:calcium ion binding; hydrolase activity; phosphoinositide phospholipase C activity [PMID 2167438]; protein binding [PMID 10873601] [PMID 14722116]; receptor signaling protein activity [PMID 7681365]; signal transducer activity
GO_process: intracellular signaling cascade; lipid catabolism; lipid metabolism
RefSeq accession NP_002651
SwissProt accession P19174
Substrate protein
Gene name FGFR4( Description: fibroblast growth factor receptor 4. )
Synonyms CD334; CD334 antigen; EC 2.7.10.1; FGFR-4; JTK2; MGC20292; TKF
GO annotations GO_component: integral to membrane; integral to plasma membrane [PMID 10918587]; membrane
GO_function:ATP binding; fibroblast growth factor receptor activity [PMID 10918587]; nucleotide binding; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: fibroblast growth factor receptor signaling pathway [PMID 10918587]; protein amino acid phosphorylation
RefSeq accession NP_002002
SwissProt accession P22455
Sequence:(RefSeq accession:NP_002002; substrate region highlighted if known)
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MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS
LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA
AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP RPPATVQKLS RFPLARQFSL
ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ
VVRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC
TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA
LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPHCPPELYG
LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS
VFSHDPLPLG SSSFPFGSGV QT
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
End of Record Details