ul_4884----
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PPBD protein
Gene name PLCG1
Synonyms EC 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C; Phospholipase C-gamma-1
GO annotations GO_component:
GO_function:calcium ion binding; hydrolase activity; phosphoinositide phospholipase C activity [PMID 2167438]; protein binding [PMID 10873601] [PMID 14722116]; receptor signaling protein activity [PMID 7681365]; signal transducer activity
GO_process: intracellular signaling cascade; lipid catabolism; lipid metabolism
RefSeq accession NP_002651
SwissProt accession P19174
Substrate protein
Gene name Fgfr1( Description: fibroblast growth factor receptor 1. )
Synonyms AW208770; FLG; Fgfr-1; Flt-2
GO annotations GO_component: membrane
GO_function:ATP binding; fibroblast growth factor receptor activity; heparin binding; kinase activity; nucleotide binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: angiogenesis; blood vessel morphogenesis; brain development; branching morphogenesis of a tube; cell maturation; embryonic limb morphogenesis; fibroblast growth factor receptor signaling pathway; induction of an organ; inner ear morphogenesis; lung development; negative regulation of apoptosis; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; protein amino acid phosphorylation; regulation of cell proliferation; salivary gland morphogenesis; signal transduction
RefSeq accession NP_034336
SwissProt accession
Sequence:(RefSeq accession:NP_034336; substrate region highlighted if known)
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MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL LQLRCRLRDD
VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA CVTSSPSGSD TTYFSVNVSD
ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK SGTKKSDFHS QMAVHKLAKS
IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF
PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PTQLANSGLK RR
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
End of Record Details