ul_4885----
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PPBD protein
Gene name PLCG1
Synonyms EC 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C; Phospholipase C-gamma-1
GO annotations GO_component:
GO_function:calcium ion binding; hydrolase activity; phosphoinositide phospholipase C activity [PMID 2167438]; protein binding [PMID 10873601] [PMID 14722116]; receptor signaling protein activity [PMID 7681365]; signal transducer activity
GO_process: intracellular signaling cascade; lipid catabolism; lipid metabolism
RefSeq accession NP_002651
SwissProt accession P19174
Substrate protein
Gene name Fgfr2( Description: fibroblast growth factor receptor 2. )
Synonyms AU043015; AW556123; Bek; Fgfr-2; Fgfr-7; Fgfr7; KGFRTr; MGC102519; svs
GO annotations GO_component: membrane; nucleus
GO_function:ATP binding; fibroblast growth factor receptor activity; heparin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: angiogenesis; bone mineralization; cell fate commitment; cell-cell signaling; embryonic organ morphogenesis; epithelial cell proliferation; fibroblast growth factor receptor signaling pathway; lung development; morphogenesis of embryonic epithelium; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; protein amino acid phosphorylation; regulation of cell proliferation; salivary gland morphogenesis; signal transduction
RefSeq accession NP_034337
SwissProt accession
Sequence:(RefSeq accession:NP_034337; substrate region highlighted if known)
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MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT TLEPEEPPTK
YQISQPEAYV VAPGESLELQ CMLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD
SGLYACTAAR TVDSETWYFM VNVTDAISSG DDEDDTDSSE DVVSENRSNQ RAPYWTNTEK
MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV
VPSDKGNYTC LVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY
SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT
CLAGNSIGIS FHSAWLTVLP APVREKEITA SPDYLEIAIY CIGVFLIACM VVTVIFCRMK
TTTKKPDFSS QPAVHKLTKR IPLRRQVTVS AESSSSMNSN TPLVRITTRL SSTADTPMLA
GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKDKPKEA VTVAVKMLKD
DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP
PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN VLVTENNVMK
IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LMWEIFTLGG
SPYPGIPVEE LFKLLKEGHR MDKPTNCTNE LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL
TLTTNEEYLD LTQPLEQYSP SYPDTRSSCS SGDDSVFSPD PMPYEPCLPQ YPHINGSVKT
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
End of Record Details