ul_5074----
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PPBD protein
Gene name PLCG1
Synonyms EC 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C; Phospholipase C-gamma-1
GO annotations GO_component:
GO_function:calcium ion binding; hydrolase activity; phosphoinositide phospholipase C activity [PMID 2167438]; protein binding [PMID 10873601] [PMID 14722116]; receptor signaling protein activity [PMID 7681365]; signal transducer activity
GO_process: intracellular signaling cascade; lipid catabolism; lipid metabolism
RefSeq accession NP_002651
SwissProt accession P19174
Substrate protein
Gene name CCKBR( Description: cholecystokinin B receptor. )
Synonyms CCK-B; CCK-B receptor; CCK-BR; CCK2-R; Cholecystokinin-2 receptor; GASR
GO annotations GO_component: integral to plasma membrane [PMID 7681836]; plasma membrane [PMID 7681836]
GO_function:gastrin receptor activity; phosphatidylinositol 3-kinase regulator activity [PMID 10400698]; phosphoinositide phospholipase C activity [PMID 7681836]; receptor activity; rhodopsin-like receptor activity
GO_process: cell proliferation [PMID 10400698]; digestion [PMID 7681836]; elevation of cytosolic calcium ion concentration [PMID 7681836]; feeding behavior [PMID 7681836]; phospholipase C activation [PMID 7681836]; positive regulation of cell proliferation [PMID 8349705]; sensory perception [PMID 7681836]
RefSeq accession NP_795344
SwissProt accession P32239
Sequence:(RefSeq accession:NP_795344; substrate region highlighted if known)
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MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL
YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF
IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL
LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL
ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS
RPALELTALT APGPGSGSRP TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY SANTWRAFDG
PGAHRALSGA PISFIHLLSY ASACVNPLVY CFMHRRFRQA CLETCARCCP RPPRARPRAL
PDEDPPTPSI ASLSRLSYTT ISTLGPG
Records:
Category Evidence Reference
A Peptide library Arnould M, Tassa A, Ferrand A, Archer E, Esteve JP, Penalba V, Portolan G, Escherich A, Moroder L, Fourmy D, Seva C, Dufresne M., The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1, [15196926]
End of Record Details