ul_5151----
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PPBD protein
Gene name PTK6( Description: PTK6 protein tyrosine kinase 6. )
Synonyms BRK; Breast tumor kinase; EC 2.7.10.2; FLJ42088; Tyrosine-protein kinase BRK
GO annotations GO_component: nucleus
GO_function:ATP binding; non-membrane spanning protein tyrosine kinase activity [PMID 8036022]; nucleotide binding; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 8036022]
RefSeq accession NP_005966
SwissProt accession Q13882
Substrate protein
Gene name PTK6( Description: PTK6 protein tyrosine kinase 6. )
Synonyms BRK; Breast tumor kinase; EC 2.7.10.2; FLJ42088; Tyrosine-protein kinase BRK
GO annotations GO_component: nucleus
GO_function:ATP binding; non-membrane spanning protein tyrosine kinase activity [PMID 8036022]; nucleotide binding; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 8036022]
RefSeq accession NP_005966
SwissProt accession Q13882
Sequence:(RefSeq accession:NP_005966; substrate region highlighted if known)
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MVSRDQAHLG PKYVGLWDFK SRTDEELSFR AGDVFHVARK EEQWWWATLL DEAGGAVAQG
YVPHNYLAER ETVESEPWFF GCISRSEAVR RLQAEGNATG AFLIRVSEKP SADYVLSVRD
TQAVRHYKIW RRAGGRLHLN EAVSFLSLPE LVNYHRAQSL SHGLRLAAPC RKHEPEPLPH
WDDWERPREE FTLCRKLGSG YFGEVFEGLW KDRVQVAIKV ISRDNLLHQQ MLQSEIQAMK
KLRHKHILAL YAVVSVGDPV YIITELMAKG SLLELLRDSD EKVLPVSELL DIAWQVAEGM
CYLESQNYIH RDLAARNILV GENTLCKVGD FGLARLIKED VYLSHDHNIP YKWTAPEALS
RGHYSTKSDV WSFGILLHEM FSRGQVPYPG MSNHEAFLRV DAGYRMPCPL ECPPSVHKLM
LTCWCRDPEQ RPCFKALRER LSSFTSYENP T
Records:
Category Evidence Reference
A Inference Qiu H, Miller WT., Role of the Brk SH3 domain in substrate recognition, [14676834]
A Structure Hong E, Shin J, Kim HI, Lee ST, Lee W., Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain, [15056653]
A Inference Kim HIe, Lee ST., An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6, [15961400]
End of Record Details