ul_519----
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PPBD protein
Gene name YWHAG( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide. )
Synonyms 14-3-3GAMMA; KCIP-1; Protein kinase C inhibitor protein 1
GO annotations GO_component: cytoplasm
GO_function:actin binding; insulin-like growth factor receptor binding [PMID 12482592]; protein domain specific binding; protein homodimerization activity; protein kinase C binding [PMID 10433554]; protein kinase C inhibitor activity [PMID 10433554]
GO_process: cytoskeleton organization and biogenesis; negative regulation of apoptosis; negative regulation of protein kinase activity [PMID 10433554]; regulation of mitosis; regulation of neuron differentiation [PMID 11824616]; regulation of signal transduction [PMID 10433554] [PMID 10486217]; regulation of synaptic plasticity [PMID 11824616]
RefSeq accession NP_036611
SwissProt accession P61981
Substrate protein
Gene name App( Description: amyloid beta (A4) precursor protein. )
Synonyms AL024401; Abeta; Adap; Cvap; E030013M08Rik; appican; betaAPP
GO annotations GO_component: apical part of cell; axon; ciliary rootlet; coated pit; cytoplasm; cytoplasmic vesicle; Golgi apparatus; integral to membrane; membrane; membrane fraction; neuromuscular junction; neuron projection; perinuclear region; spindle midzone
GO_function:binding; copper ion binding; DNA binding; endopeptidase inhibitor activity; heparin binding; iron ion binding; metal ion binding; protein binding; serine-type endopeptidase inhibitor activity; zinc ion binding
GO_process: adult locomotory behavior; apoptosis; axon cargo transport; axon midline choice point recognition; axonogenesis; cell adhesion; collateral sprouting in the absence of injury; copper ion homeostasis; dendrite development; endocytosis; extracellular matrix organization and biogenesis; forebrain development; G2 phase of mitotic cell cycle; locomotory behavior; mating behavior; mRNA polyadenylation; neurite development; neuron remodeling; Notch signaling pathway; positive regulation of progression through mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; regulation of balance; regulation of body size; regulation of synapse structure and function; regulation of translation; smooth endoplasmic reticulum calcium ion homeostasis; suckling behavior; synaptic growth at neuromuscular junction; visual learning
RefSeq accession NP_031497
SwissProt accession P12023
GO Pathway:
GO:0045449     regulation of transcription
Sequence:(RefSeq accession:NP_031497; substrate region highlighted if known)
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MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV
DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK ADKKAVIQHF
QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN YITALQAVPP RPHHVFNMLK
KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ IRSQVMTHLR VIYERMNQSL SLLYNVPAVA
EEIQDEVDEL LQKEQNYSDD VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL
DDLQPWHPFG VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF
GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK KQYTSIHHGV
VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN
Records:
Category Evidence Reference
A Mutagenesis Sumioka A, Nagaishi S, Yoshida T, Lin A, Miura M, Suzuki T., Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment., [16223726]
End of Record Details