ul_5232----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name KIR2DL3( Description: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3. )
Synonyms CD158B2; CD158b; GL183; KIR-023GB; KIR-K7b; KIR-K7c; KIRCL23; MGC129943; MHC class I NK cell receptor; NKAT; NKAT-2; NKAT2; NKAT2A; NKAT2B; NKAT2a; NKAT2b; Natural killer-associated transcript 2; p58; p58 NK receptor; p58 natural killer cell receptor clone CL-6; p58.2 MHC c
GO annotations GO_component: integral to plasma membrane [PMID 9059894]; membrane
GO_function:antigen binding [PMID 9059894]; receptor activity [PMID 7749980]
GO_process: immune response [PMID 7749980]
RefSeq accession NP_056952
SwissProt accession P43628
Sequence:(RefSeq accession:NP_056952; substrate region highlighted if known)
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MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFQHFLL
HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN
PRHLHVLIGT SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
Records:
Category Evidence Reference
A Peptide library Olcese L, Lang P, Vely F, Cambiaggi A, Marguet D, Blery M, Hippen KL, Biassoni R, Moretta A, Moretta L, Cambier JC, Vivier E., Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases, [8648092]
End of Record Details