ul_5307----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name Ptpns1( Description: protein tyrosine phosphatase, non-receptor type substrate 1. )
Synonyms Bit; SHPS-1
GO annotations GO_component: extracellular space; integral to membrane; integral to plasma membrane; membrane; plasma membrane
GO_function:protein binding; protein phosphorylated amino acid binding
GO_process: actin filament organization; cell adhesion; cell migration; cell motility; cell-matrix adhesion; cytoskeleton organization and biogenesis; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis
RefSeq accession NP_037148
SwissProt accession
GO Pathway:
GO:0000187     activation of MAPK activity
Sequence:(RefSeq accession:NP_037148; substrate region highlighted if known)
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MEPAGPAPGR LGPLLFCLLL SASCICAGAS GKELKVTQAD KSVSVAAGDS ATLNCTVSSL
TPVGPIKWFK GEGQNRSPIY SFIGGEHFPR ITNVSDATKR NNMDFSICIS NVTPEDAGTY
YCVKFQKGIV EPDTEIKSGG GTTLYVLAKP SSPEVSGPDS RGSPGQTVNF TCKSYGFSPR
NITLKWLKNG KELSHLETTI SSKSNVSYNI SSTVSVKLSP EDIHSRVICE VAHVTLEGRP
LNGTANFSNI IRVSPTLKIT QQPLTPASQV NLTCQVQKFY PKALQLNWLE NGNLSRTDKP
EHFTDNRDGT YNYTSLFLVN SSAHREDVVF TCQVEHDSQP AITENHTVRA FAHSSSGGSM
ETIPDNNAYY NWNVFIGVGV ACALLVVLLM AALYLLRIKQ KKAKGSTSST RLHEPEKNAR
EITQIQDTND INDITYADLN LPKEKKPAPR VPEPNNHTEY ASIETGKLPR PEDTLTYADL
DMVHLNRAQP TPKPEPSFSE YASVQVQRK
Records:
Category Evidence Reference
A Inference Tsuda M, Matozaki T, Fukunaga K, Fujioka Y, Imamoto A, Noguchi T, Takada T, Yamao T, Takeda H, Ochi F, Yamamoto T, Kasuga M., Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases, [9582366]
End of Record Details