ul_5319----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name Lilrb3( Description: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3. )
Synonyms Gp91; Pirb
GO annotations GO_component:
GO_function:receptor activity
GO_process: B cell homeostasis; B cell mediated immunity; cytokine and chemokine mediated signaling pathway; myeloid dendritic cell differentiation
RefSeq accession NP_035225
SwissProt accession
GO Pathway:
GO:0006470     protein amino acid dephosphorylation
Sequence:(RefSeq accession:NP_035225; substrate region highlighted if known)
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MSCTFTALLR LGLTLSLWIP VLTGSLPKPI LRVQPDSVVS RWTKVTFFCE ETIGANEYRL
YKDGKLYKTV TKNKQKPANK AEFSLSNVDL RNAGQYRCSY STQYKSSGYS DPLELVVTGD
YWTPSLLAQA SPVVTSGGYV TLQCESWHND HKFILTVEGP QKLSWTQDSQ YNYSTRKYHA
LFSVGPVTPN QRWICRCYSY DRNRPYVWSP PSESVELLVS GNLQKPTIKA EPGPVIASKR
AMTIWCQGNL DAEVYFLHNE GSQKTQSTQT LQQPGNKGKF FIPSMTRQHA GQYRCYCYGS
AGWSQPSDTL ELVVTGIYEH YKPRLSVLPS PVVTAGGNMT LHCASDFHYD KFILTKEDKK
FGNSLDTEHI SSSRQYRALF IIGPTTPTHT GTFRCYGYFK NAPQLWSVPS DLQQILISGL
SKKPSLLTHQ GHILDPGMTL TLQCYSDINY DRFALHKVGG ADIMQHSSQQ TDTGFSVANF
TLGYVSSSTG GQYRCYGAHN LSSEWSASSE PLDILITGQL PLTPSLSVKP NHTVHSGETV
SLLCWSMDSV DTFILSKEGS AQQPLRLKSK SHDQQSQAEF SMSAVTSHLS GTYRCYGAQN
SSFYLLSSAS APVELTVSGP IETSTPPPTM SMPLGGLHMY LKALIGVSVA FILFLFILIF
ILLRRRHRGK FRKDVQKEKD LQLSSGAEEP ITRKGELQKR PNPAAATQEE SLYASVEDMQ
TEDGVELNSW TPPEEDPQGE TYAQVKPSRL RKAGHVSPSV MSREQLNTEY EQAEEGQGAN
NQAAESGESQ DVTYAQLCSR TLRQGAAASP LSQAGEAPEE PSVYATLAAA RPEAVPKDVE
Q
Records:
Category Evidence Reference
A Timms JF, Carlberg K, Gu H, Chen H, Kamatkar S, Nadler MJ, Rohrschneider LR, Neel BG., Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages, [9632768]
End of Record Details