ul_5345----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name Ceacam1( Description: CEA-related cell adhesion molecule 1. )
Synonyms Bgp; Bgp1; C-CAM; CD66a; Cea-1; Cea-7; Cea1; Cea7; Hv-2; Hv2; MHVR; Mhv-1; bb-1; mCEA1; mmCGM1; mmCGM1a; mmCGM2
GO annotations GO_component: integral to membrane; membrane
GO_function:receptor activity
GO_process: positive regulation of MAPK activity
RefSeq accession NP_001034274
SwissProt accession
Sequence:(RefSeq accession:NP_001034274; substrate region highlighted if known)
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MELASAHLHK GQVPWGGLLL TASLLASWSP ATTAEVTIEA VPPQVAEDNN VLLLVHNLPL
ALGAFAWYKG NTTAIDKEIA RFVPNSNMNF TGQAYSGREI IYSNGSLLFQ MITMKDMGVY
TLDMTDENYR RTQATVRFHV HPILLKPNIT SNNSNPVEGD DSVSLTCDSY TDPDNINYLW
SRNGESLSEG DRLKLSEGNR TLTLLNVTRN DTGPYVCETR NPVSVNRSDP FSLNIIYGPD
TPIISPSDIY LHPGSNLNLS CHAASNPPAQ YFWLINEKPH ASSQELFIPN ITTNNSGTYT
CFVNNSVTGL SRTTVKNITV LEPVTQPFLQ VTNTTVKELD SVTLTCLSND IGANIQWLFN
SQSLQLTERM TLSQNNSILR IDPIKREDAG EYQCEISNPV SVRRSNSIKL DIIFDPTQGG
LSDGAIAGIV IGVVAGVALI AGLAYFLYSR KSGGGSDQRD LTEHKPSASN HNLAPSDNSP
NKVDDVAYTV LNFNSQQPNR PTSAPSSPRA TETVYSEVKK K
Records:
Category Evidence Reference
A Mutagenesis Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N., The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells, [9867848]
End of Record Details