ul_5388----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name Lepr( Description: leptin receptor. )
Synonyms LEPROT; MGC105189; OB-RGRP; Obr; db; diabetes; obese-like; obl
GO annotations GO_component: integral to plasma membrane; membrane
GO_function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity; transmembrane receptor activity
GO_process: regulation of metabolism; signal transduction
RefSeq accession NP_666258
SwissProt accession
GO Pathway:
GO:0000165     MPKKK cascade
Sequence:(RefSeq accession:NP_666258; substrate region highlighted if known)
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MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL
KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF
RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS
FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL
GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS
SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY
AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT
SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN
VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL
LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA
SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG
MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL
YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH
AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS SICISDQCNS
ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE QGFIHSPVSN CISSNHSPLR
QSFSSSSWET EAQTFFLLSD QQPTMISPQL SFSGLDELLE LEGSFPEENH REKSVCYLGV
TSVNRRESGV LLTGEAGILC TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP
QFQTCSTHSH KIMENKMCDL TVQSHPKSLK VPFQ
Records:
Category Evidence Reference
A Inference Banks AS, Davis SM, Bates SH, Myers MG Jr., Activation of downstream signals by the long form of the leptin receptor, [10799542]
End of Record Details