ul_5427----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name C6orf25
Synonyms
GO annotations GO_component: endoplasmic reticulum; integral to membrane; plasma membrane [PMID 11544253]
GO_function:receptor activity
GO_process:
RefSeq accession NP_612116
SwissProt accession O95866
Sequence:(RefSeq accession:NP_612116; substrate region highlighted if known)
1
61
121
181
241
MAVFLQLLPL LLSRAQGNPG ASLDGRPGDR VNLSCGGVSH PIRWVWAPSF PACKGLSKGR
RPILWASSSG TPTVPPLQPF VGRLRSLDSG IRRLELLLSA GDSGTFFCKG RHEDESRTVL
HVLGDRTYCK APGPTHGSVY PQLLIPLLGA GLVLGLGALG LVWWLHRRLP PQPIRPLPRF
APLVKTEPQR PVKEEEPKIP GDLDQEPSLL YADLDHLALS RPRRLSTADP ADASTIYAVV
V
Records:
Category Evidence Reference
A Mutagenesis de Vet EC, Aguado B, Campbell RD., G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2, [11544253]
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details