ul_5430----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name SELE( Description: selectin E (endothelial adhesion molecule 1). )
Synonyms CD62E; CD62E antigen; ELAM; ELAM-1; ELAM1; ESEL; Endothelial leukocyte adhesion molecule 1; LECAM2; Leukocyte-endothelial cell adhesion molecule 2
GO annotations GO_component: integral to membrane; membrane; plasma membrane [PMID 2466335]
GO_function:protein binding; sugar binding
GO_process: cell adhesion; inflammatory response [PMID 2466335]
RefSeq accession NP_000441
SwissProt accession P16581
GO Pathway:
KEGG:04630     Jak-STAT signaling pathway
Sequence:(RefSeq accession:NP_000441; substrate region highlighted if known)
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MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN
SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK
DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC
TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV
ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP
VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN
EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELYGS TQLECTSQGQ
WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW
SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
GSYQKPSYIL
Records:
Category Evidence Reference
A Mutagenesis Hu Y, Szente B, Kiely JM, Gimbrone MA Jr., Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation, [11602579]
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details