ul_5435----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name MPZL1
Synonyms
GO annotations GO_component: integral to plasma membrane [PMID 9792637]; membrane
GO_function:protein binding [PMID 10681522] [PMID 15231747]; structural molecule activity [PMID 9792637]
GO_process: cell-cell signaling [PMID 9792637]; transmembrane receptor protein tyrosine kinase signaling pathway [PMID 10681522]
RefSeq accession NP_003944
SwissProt accession O95297
GO Pathway:
GO:0007267     cell-cell signaling
Sequence:(RefSeq accession:NP_003944; substrate region highlighted if known)
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241
MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF
KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI
NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT
LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI
YAQLDHSGGH HSDKINKSES VVYADIRKN
Records:
Category Evidence Reference
A Inference Zhao R, Guerrah A, Tang H, Zhao ZJ., Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling, [11751924]
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details