ul_5470----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name Agtr1a( Description: angiotensin II receptor, type 1 (AT1A). )
Synonyms AT1; AT1A; AT1R
GO annotations GO_component: cytoplasm; cytoplasmic vesicle; dendrite; endomembrane system; endosome; Golgi apparatus; integral to membrane; organelle outer membrane; plasma membrane
GO_function:angiotensin type I receptor activity; peptide hormone binding; protein binding; receptor activity
GO_process: angiotensin mediated regulation of renal output; blood pressure regulation; blood vessel development; brain renin-angiotensin system; drinking behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); kidney development; positive regulation of receptor recycling; regulation of blood pressure by circulatory renin-angiotensin; regulation of pH; renin secretion into blood stream; renin-angiotensin regulation of aldosterone production; signal transduction
RefSeq accession NP_112247
SwissProt accession
GO Pathway:
GO:0007186     G-protein coupled receptor protein signaling pathway
Sequence:(RefSeq accession:NP_112247; substrate region highlighted if known)
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MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK KPASCFEVE
Records:
Category Evidence Reference
A Inference Seta K, Sadoshima J., Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor, [12522132]
End of Record Details