ul_5493----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name PDCD1( Description: programmed cell death 1. )
Synonyms CD279; CD279 antigen; PD1; Protein PD-1; SLEB2; hPD-1; hPD-l
GO annotations GO_component: integral to membrane; membrane
GO_function:signal transducer activity [PMID 1396582]
GO_process: apoptosis [PMID 1396582]; development [PMID 9332365]; humoral immune response [PMID 9332365]
RefSeq accession NP_005009
SwissProt accession Q15116
GO Pathway:
GO:0006915     apoptosis
Sequence:(RefSeq accession:NP_005009; substrate region highlighted if known)
1
61
121
181
241
MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFFPA LLVVTEGDNA TFTCSFSNTS
ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT
YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS
LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP
CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL
Records:
Category Evidence Reference
A Mutagenesis Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL., SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation, [15240681]
End of Record Details