ul_551----
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PPBD protein
Gene name YWHAH( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide. )
Synonyms YWHA1
GO annotations GO_component: cytoplasm
GO_function:actin binding; glucocorticoid receptor binding [PMID 9079630]; insulin-like growth factor receptor binding; protein domain specific binding; protein kinase C inhibitor activity; transcriptional activator activity [PMID 15790729]
GO_process: cytoskeleton organization and biogenesis; glucocorticoid catabolism [PMID 15790729]; glucocorticoid receptor signaling pathway [PMID 15790729]; intracellular protein transport; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of protein kinase activity; positive regulation of transcription [PMID 15790729]; regulation of mitosis; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity
RefSeq accession NP_003396
SwissProt accession Q04917
Substrate protein
Gene name CDC25C
Synonyms Dual specificity phosphatase Cdc25C; EC 3.1.3.48
GO annotations GO_component: intracellular; nucleus
GO_function:hydrolase activity; protein tyrosine phosphatase activity [PMID 11078813]
GO_process: cell cycle; cell division; cell proliferation [PMID 11139144]; protein amino acid dephosphorylation; regulation of cyclin-dependent protein kinase activity [PMID 11139144]; regulation of mitosis [PMID 1828290]; traversing start control point of mitotic cell cycle [PMID 2195549]
RefSeq accession NP_001781
SwissProt accession P30307
GO Pathway:
GO:0007049     cell cycle
Sequence:(RefSeq accession:NP_001781; substrate region highlighted if known)
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MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
SILSGGTPKC CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP
Records:
Category Evidence Reference
A Mutagenesis Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H., Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis., [9278512]
End of Record Details