ul_5510----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name ADCY2( Description: adenylate cyclase 1 (brain). )
Synonyms ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2; EC 4.6.1.1
GO annotations GO_component: integral to membrane; membrane
GO_function:adenylate cyclase activity [PMID 1427768]; magnesium ion binding
GO_process: cAMP biosynthesis; cyclic nucleotide biosynthesis; intracellular signaling cascade
RefSeq accession NP_065433
SwissProt accession Q08462
Sequence:(RefSeq accession:NP_065433; substrate region highlighted if known)
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MRRRRYLRDR SEEAAGGGDG LPRSRDWLYE SYYCMSQQHP LIVFLLLIVM GSCLALLAVF
FALGLEVEDH VAFLITVPTA LAIFFAIFIL VCIESVFKKL LRLFSLVIWI CLVAMGYLFM
CFGGTVSPWD QVSFFLFIIF VVYTMLPFNM RDAIIASVLT SSSHTIVLSV CLSATPGGKE
HLVWQILANV IIFICGNLAG AYHKHLMELA LQQTYQDTCN CIKSRIKLEF EKRQQERLLL
SLLPAHIAME MKAEIIQRLQ GPKAGQMENT NNFHNLYVKR HTNVSILYAD IVGFTRLASD
CSPGELVHML NELFGKFDQI AKENECMRIK ILGDCYYCVS GLPISLPNHA KNCVKMGLDM
CEAIKKVRDA TGVDINMRVG VHSGNVLCGV IGLQKWQYDV WSHDVTLANH MEAGGVPGRV
HISSVTLEHL NGAYKVEEGD GDIRDPYLKQ HLVKTYFVIN PKGERRSPQH LFRPRHTLDG
AKMRASVRMT RYLESWGAAK PFAHLHHRDS MTTENGKIST TDVPMGQHNF QNRTLRTKSQ
KKRFEEELNE RMIQAIDGIN AQKQWLKSED IQRISLLFYN KVLEKEYRAT ALPAFKYYVT
CACLIFFCIF IVQILVLPKT SVLGISFGAA FLLLAFILFV CFAGQLLQCS KKASPLLMWL
LKSSGIIANR PWPRISLTII TTAIILMMAV FNMFFLSDSE ETIPPTANTT NTSFSASNNQ
VAILRAQNLF FLPYFIYSCI LGLISCSVFL RVNYELKMLI MMVALVGYNT ILLHTHAHVL
GDYSQVLFER PGIWKDLKTM GSVSLSIFFI TLLVLGRQNE YYCRLDFLWK NKFKKEREEI
ETMENLNRVL LENVLPAHVA EHFLARSLKN EELYHQSYDC VCVMFASIPD FKEFYTESDV
NKEGLECLRL LNEIIADFDD LLSKPKFSGV EKIKTIGSTY MAATGLSAVP SQEHSQEPER
QYMHIGTMVE FAFALVGKLD AINKHSFNDF KLRVGINHGP VIAGVIGAQK PQYDIWGNTV
NVASRMDSTG VLDKIQVTEE TSLVLQTLGY TCTCRGIINV KGKGDLKTYF VNTEMSRSLS
QSNVAS
Records:
Category Evidence Reference
A Inference Qin C, Wavreille AS, Pei D., Alternative mode of binding to phosphotyrosyl peptides by Src homology-2 domains, [16142918]
End of Record Details