ul_5511----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name IL8RA( Description: interleukin 8 receptor, alpha. )
Synonyms C-C; C-C CKR-1; C-C-CKR-1; CD128; CD181; CD181 antigen; CDw128a; CKR-1; CMKAR1; CXCR-1; CXCR1; IL-8 receptor type 1; IL-8R A; IL8R1; IL8RBA
GO annotations GO_component: integral to membrane; membrane [PMID 10725748]
GO_function:interleukin-8 receptor activity [PMID 10734056]; receptor activity; rhodopsin-like receptor activity
GO_process: chemotaxis [PMID 10725748]; G-protein coupled receptor protein signaling pathway [PMID 8381837]; inflammatory response [PMID 10725748]
RefSeq accession NP_000625
SwissProt accession P25024
Sequence:(RefSeq accession:NP_000625; substrate region highlighted if known)
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MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV
MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN
FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP
NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA
MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Records:
Category Evidence Reference
A Inference Qin C, Wavreille AS, Pei D., Alternative mode of binding to phosphotyrosyl peptides by Src homology-2 domains, [16142918]
End of Record Details