ul_5522----
Record details: Hide
PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name SIGLEC11( Description: sialic acid binding Ig-like lectin 11. )
Synonyms Sialic acid-binding lectin 11; Siglec-11
GO annotations GO_component: integral to membrane; membrane
GO_function:protein binding; sugar binding
GO_process: cell adhesion
RefSeq accession NP_443116
SwissProt accession Q96RL6
Sequence:(RefSeq accession:NP_443116; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
661
MLLLPLLLPV LGAGSLNKDP SYSLQVQRQV PVPEGLCVIV SCNLSYPRDG WDESTAAYGY
WFKGRTSPKT GAPVATNNQS REVEMSTRDR FQLTGDPGKG SCSLVIRDAQ REDEAWYFFR
VERGSRVRHS FLSNAFFLKV TALTKKPDVY IPETLEPGQP VTVICVFNWA FKKCPAPSFS
WTGAALSPRR TRPSTSHFSV LSFTPSPQDH DTDLTCHVDF SRKGVSAQRT VRLRVAYAPK
DLIISISHDN TSALELQGNV IYLEVQKGQF LRLLCAADSQ PPATLSWVLQ DRVLSSSHPW
GPRTLGLELR GVRAGDSGRY TCRAENRLGS QQQALDLSVQ YPPENLRVMV SQANRTVLEN
LGNGTSLPVL EGQSLRLVCV THSSPPARLS WTRWGQTVGP SQPSDPGVLE LPPIQMEHEG
EFTCHAQHPL GSQHVSLSLS VHYPPQLLGP SCSWEAEGLH CSCSSQASPA PSLRWWLGEE
LLEGNSSQGS FEVTPSSAGP WANSSLSLHG GLSSGLRLRC KAWNVHGAQS GSVFQLLPGK
LEHGGGLGLG AALGAGVAAL LAFCSCLVVF RVKICRKEAR KRAAAEQDVP STLGPISQGH
QHECSAGSSQ DHPPPGAATY TPGKGEEQEL HYASLSFQGL RLWEPADQEA PSTTEYSEIK
IHTGQPLRGP GFGLQLEREM SGMVPK
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details