ul_5530----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name SACS( Description: spastic ataxia of Charlevoix-Saguenay (sacsin). )
Synonyms ARSACS; DKFZp686B15167
GO annotations GO_component:
GO_function:ATP binding; heat shock protein binding
GO_process: protein folding [PMID 10655055]; protein modification
RefSeq accession NP_055178
SwissProt accession Q9NZJ4
Sequence:(RefSeq accession:NP_055178; substrate region highlighted if known)
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MAPYQGPALY VYNNAVFTPE DWHGIQEIAR SRKKDDPLKV GRFGIGFNSV YHITDVPCIF
SGDQIGMLDP HQTLFGPHES GQCWNLKDDS KEISELSDQF APFVGIFGST KETFINGNFP
GTFFRFPLRL QPSQLSSNLY NKQKVLELFE SFRADADTVL LFLKSVQDVS LYVREADGTE
KLVFRVTSSE SKALKHERPN SIKILGTAIS NYCKKTPSNN ITCVTYHVNI VLEEESTKDA
QKTSWLVCNS VGGRGISSKL DSLADELKFV PIIGIAMPLS SRDDEAKGAT SDFSGKAFCF
LPLPPGEESS TGLPVHISGF FGLTDNRRSI KWRELDQWRD PAALWNEFLV MNVVPKAYAT
LILDSIKRLE MEKSSDFPLS VDVIYKLWPE ASKVKVHWQP VLEPLFSELL QNAVIYSISC
DWVRLEQVYF SELDENLEYT KTVLNYLQSS GKQIAKVPGN VDAAVQLTAA SGTTPVRKVT
PAWVRQVLRK CAHLGCAEEK LHLLEFVLSD QAYSELLGLE LLPLQNGNFV PFSSSVSDQD
VIYITSAEYP RSLFPSLEGR FILDNLKPHL VAALKEAAQT RGRPCTQLQL LNPERFARLI
KEVMNTFWPG RELIVQWYPF DENRNHPSVS WLKMVWKNLY IHFSEDLTLF DEMPLIPRTI
LEEGQTCVEL IRLRIPSLVI LDDESEAQLP EFLADIVQKL GGFVLKKLDA SIQHPLIKKY
IHSPLPSAVL QIMEKMPLQK LCNQITSLLP THKDALRKFL ASLTDSSEKE KRIIQELAIF
KRINHSSDQG ISSYTKLKGC KVLHHTAKLP ADLRLSISVI DSSDEATIRL ANMLKIEQLK
TTSCLKLVLK DIENAFYSHE EVTQLMLWVL ENLSSLKNEN PNVLEWLTPL KFIQISQEQM
VSAGELFDPD IEVLKDLFCN EEGTYFPPSV FTSPDILHSL RQIGLKNEAS LKEKDVVQVA
KKIEALQVGA CPDQDVLLKK AKTLLLVLNK NHTLLQSSEG KMTLKKIKWV PACKERPPNY
PGSLVWKGDL CNLCAPPDMC DVGHAILIGS SLPLVESIHV NLEKALGIFT KPSLSAVLKH
FKIVVDWYSS KTFSDEDYYQ FQHILLEIYG FMHDHLNEGK DSFRALKFPW VWTGKKFCPL
AQAVIKPIHD LDLQPYLHNV PKTMAKFHQL FKVCGSIEEL TSDHISMVIQ KIYLKSDQDL
SEQESKQNLH LMLNIIRWLY SNQIPASPNT PVPIHHSKNP SKLIMKPIHE CCYCDIKVDD
LNDLLEDSVE PIILVHEDIP MKTAEWLKVP CLSTRLINPE NMGFEQSGQR EPLTVRIKNI
LEEYPSVSDI FKELLQNADD ANATECSFLI DMRRNMDIRE NLLDPGMAAC HGPALWSFNN
SQFSDSDFVN ITRLGESLKR GEVDKVGKFG LGFNSVYHIT DIPIIMSREF MIMFDPNINH
ISKHIKDKSN PGIKINWSKQ QKRLRKFPNQ FKPFIDVFGC QLPLTVEAPY SYNGTLFRLS
FRTQQEAKVS EVSSTCYNTA DIYSLVDEFS LCGHRLIIFT QSVKSMYLKY LKIEETNPSL
AQDTVIIKKK SCSSKALNTP VLSVLKEAAK LMKTCSSSNK KLPSDEPKSS CILQITVEEF
HHVFRRIADL QSPLFRGPDD DPAALFEMAK SGQSKKPSDE LSQKTVECTT WLLCTCMDTG
EALKFSLSES GRRLGLVPCG AVGVQLSEIQ DQKWTVKPHI GEVFCYLPLR IKTGLPVHIN
GCFAVTSNRK EIWKTDTKGR WNTTFMRHVI VKAYLQVLSV LRDLATSGEL MDYTYYAVWP
DPDLVHDDFS VICQGFYEDI AHGKGKELTK VFSDGSTWVS MKNVRFLDDS ILKRRDVGSA
AFKIFLKYLK KTGSKNLCAV ELPSSVKLGF EEAGCKQILL ENTFSEKQFF SEVFFPNIQE
IEAELRDPLM IFVLNEKVDE FSGVLRVTPC IPCSLEGHPL VLPSRLIHPE GRVAKLFDIK
DGRFPYGSTQ DYLNPIILIK LVQLGMAKDD ILWDDMLERA VSVAEINKSD HVAACLRSSI
LLSLIDEKLK IRDPRAKDFA AKYQTIRFLP FLTKPAGFSL DWKGNSFKPE TMFAATDLYT
AEHQDIVCLL QPILNENSHS FRGCGSVSLA VKEFLGLLKK PTVDLVINQL KEVAKSVDDG
ITLYQENITN ACYKYLHEAL MQNEITKMSI IDKLKPFSFI LVENAYVDSE KVSFHLNFEA
APYLYQLPNK YKNNFRELFE TVGVRQSCTV EDFALVLESI DQERGTKQIT EENFQLCRRI
ISEGIWSLIR EKKQEFCEKN YGKILLPDTN LMLLPAKSLC YNDCPWIKVK DTTVKYCHAD
IPREVAVKLG AVPKRHKALE RYASNVCFTT LGTEFGQKEK LTSRIKSILN AYPSEKEMLK
ELLQNADDAK ATEICFVFDP RQHPVDRIFD DKWAPLQGPA LCVYNNQPFT EDDVRGIQNL
GKGTKEGNPY KTGQYGIGFN SVYHITDCPS FISGNDILCI FDPHARYAPG ATSISPGRMF
RDLDADFRTQ FSDVLDLYLG THFKLDNCTM FRFPLRNAEM AKVSEISSVP ASDRMVQNLL
DKLRSDGAEL LMFLNHMEKI SICEIDKSTG ALNVLYSVKG KITDGDRLKR KQFHASVIDS
VTKKRQLKDI PVQQITYTMD TEDSEGNLTT WLICNRSGFS SMEKVSKSVI SAHKNQDITL
FPRGGVAACI THNYKKPHRA FCFLPLSLET GLPFHVNGHF ALDSARRNLW RDDNGVGVRS
DWNNSLMTAL IAPAYVELLI QLKKRYFPGS DPTLSVLQNT PIHVVKDTLK KFLSFFPVNR
LDLQPDLYCL VKALYNCIHE DMKRLLPVVR APNIDGSDLH SAVIITWINM STSNKTRPFF
DNLLQDELQH LKNADYNITT RKTVAENVYR LKHLLLEIGF NLVYNCDETA NLYHCLIDAD
IPVSYVTPAD IRSFLMTFSS PDTNCHIGKL PCRLQQTNLK LFHSLKLLVD YCFKDAEENE
IEVEGLPLLI TLDSVLQTFD AKRPKFLTTY HELIPSRKDL FMNTLYLKYS NILLNCKVAK
VFDISSFADL LSSVLPREYK TKSCTKWKDN FASESWLKNA WHFISESVSV KEDQEETKPT
FDIVVDTLKD WALLPGTKFT VSANQLVVPE GDVLLPLSLM HIAVFPNAQS DKVFHALMKA
GCIQLALNKI CSKDSAFVPL LSCHTANIES PTSILKALHY MVQTSTFRAE KLVENDFEAL
LMYFNCNLNH LMSQDDIKIL KSLPCYKSIS GRYVSIGKFG TCYVLTKSIP SAEVEKWTQS
SSSAFLEEKI HLKELYEVIG CVPVDDLEVY LKHLLPKIEN LSYDAKLEHL IYLKNRLSSA
EELSEIKEQL FEKLESLLII HDANSRLKQA KHFYDRTVRV FEVMLPEKLF IPNDFFKKLE
QLIKPKNHVT FMTSWVEFLR NIGLKYILSQ QQLLQFAKEI SVRANTENWS KETLQNTVDI
LLHHIFQERM DLLSGNFLKE LSLIPFLCPE RAPAEFIRFH PQYQEVNGTL PLIKFNGAQV
NPKFKQCDVL QLLWTSCPIL PEKATPLSIK EQEGSDLGPQ EQLEQVLNML NVNLDPPLDK
VINNCRNICN ITTLDEEMVK TRAKVLRSIY EFLSAEKREF RFQLRGVAFV MVEDGWKLLK
PEEVVINLEY ESDFKPYLYK LPLELGTFHQ LFKHLGTEDI ISTKQYVEVL SRIFKNSEGK
QLDPNEMRTV KRVVSGLFRS LQNDSVKVRS DLENVRDLAL YLPSQDGRLV KSSILVFDDA
PHYKSRIQGN IGVQMLVDLS QCYLGKDHGF HTKLIMLFPQ KLRPRLLSSI LEEQLDEETP
KVCQFGALCS LQGRLQLLLS SEQFITGLIR IMKHENDNAF LANEEKAIRL CKALREGLKV
SCFEKLQTTL RVKGFNPIPH SRSETFAFLK RFGNAVILLY IQHSDSKDIN FLLALAMTLK
SATDNLISDT SYLIAMLGCN DIYRIGEKLD SLGVKYDSSE PSKLELPMPG TPIPAEIHYT
LLMDPMNVFY PGEYVGYLVD AEGGDIYGSY QPTYTYAIIV QEVEREDADN SSFLGKIYQI
DIGYSEYKIV SSLDLYKFSR PEESSQSRDS APSTPTSPTE FLTPGLRSIP PLFSGRESHK
TSSKHQSPKK LKVNSLPEIL KEVTSVVEQA WKLPESERKK IIRRLYLKWH PDKNPENHDI
ANEVFKHLQN EINRLEKQAF LDQNADRASR RTFSTSASRF QSDKYSFQRF YTSWNQEATS
HKSERQQQNK EKCPPSAGQT YSQRFFVPPT FKSVGNPVEA RRWLRQARAN FSAARNDLHK
NANEWVCFKC YLSTKLALIA ADYAVRGKSD KDVKPTALAQ KIEEYSQQLE GLTNDVHTLE
AYGVDSLKTR YPDLLPFPQI PNDRFTSEVA MRVMECTACI IIKLENFMQQ KV
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details