ul_5544----
Record details: Hide
PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name KIR3DL1( Description: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1. )
Synonyms CD158E1; CD158e antigen; HLA-BW4-specific inhibitory NK cell receptor; KIR; MGC119726; MGC119728; MGC126589; MGC126591; MHC class I NK cell receptor; NKAT-3; NKAT3; NKB1; NKB1B; Natural killer-associated transcript 3; p70 natural killer cell receptor clones CL-2/CL-11
GO annotations GO_component: integral to plasma membrane [PMID 7716543] [PMID 8662091]; membrane
GO_function:HLA-B specific inhibitory MHC class I receptor activity [PMID 7650366] [PMID 8662091]; MHC class I receptor activity [PMID 8662091]; receptor activity
GO_process: immune response [PMID 7716543] [PMID 8662091]; natural killer cell activation [PMID 8662091]
RefSeq accession NP_037421
SwissProt accession P43629
Sequence:(RefSeq accession:NP_037421; substrate region highlighted if known)
1
61
121
181
241
301
361
421
MLLMVVSMAC VGFFLVQRAG PHVGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML
YKEDRIHVPI FHGRLFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV
TLSCSSRSSY DMYHLSRERG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT
PPTDTILYTE LPNAKPRSKV VSCP
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details