ul_5557----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name SIGLEC6( Description: sialic acid binding Ig-like lectin 6. )
Synonyms CD327 antigen; CD33 antigen-like 1; CD33L; CD33L1; CDw327; OB-BP1; OBBP1; Obesity-binding protein 1; SIGLEC-6; Siglec-6
GO annotations GO_component: integral to plasma membrane [PMID 9465907]; membrane; membrane fraction [PMID 9465907]
GO_function:protein binding; sugar binding
GO_process: cell adhesion; cell-cell signaling [PMID 9465907]
RefSeq accession NP_001236
SwissProt accession O43699
Sequence:(RefSeq accession:NP_001236; substrate region highlighted if known)
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MLPLLLPLLW AGALAQERRF QLEGPESLTV QEGLCVLVPC RLPTTLPASY YGYGYWFLEG
ADVPVATNDP DEEVQEETRG RFHLLWDPRR KNCSLSIRDA RRRDNAAYFF RLKSKWMKYG
YTSSKLSVRV MALTHRPNIS IPGTLESGHP SNLTCSVPWV CEQGTPPIFS WMSAAPTSLG
PRTTQSSVLT ITPRPQDHST NLTCQVTFPG AGVTMERTIQ LNVSYAPQKV AISIFQGNSA
AFKILQNTSS LPVLEGQALR LLCDADGNPP AHLSWFQGFP ALNATPISNT GVLELPQVGS
AEEGDFTCRA QHPLGSLQIS LSLFVHWKPE GRAGGVLGAV WGASITTLVF LCVCFIFRVK
TRRKKAAQPV QNTDDVNPVM VSGSRGHQHQ FQTGIVSDHP AEAGPISEDE QELHYAVLHF
HKVQPQEPKV TDTEYSEIKI HK
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details