ul_5560----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name SIGLEC12
Synonyms Sialic acid-binding Ig-like lectin-like 1; Siglec-12; Siglec-L1
GO annotations GO_component: integral to membrane; membrane
GO_function:protein binding; sugar binding
GO_process: cell adhesion
RefSeq accession NP_201586
SwissProt accession Q96PQ1
Sequence:(RefSeq accession:NP_201586; substrate region highlighted if known)
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MLLPLLWANE ERDSGGWADP RFSTASQDLL SRYRLEVPES VTVQEGLCVS VPCSVLYPHY
NWTASSPVYG SWFKEGADIP WDIPVATNTP SGKVQEDTHG RFLLLGDPQT NNCSLSIRDA
RKGDSGKYYF QVERGSRKWN YIYDKLSVHV TALTHMPTFS IPGTLESGHP RNLTCSVPWA
CEQGTPPTIT WMGASVSSLD PTITRSSMLS LIPQPQDHGT SLTCQVTLPG AGVTMTRAVR
LNISYPPQNL TMTVFQGDGT ASTTLRNGSA LSVLEGQSLH LVCAVDSNPP ARLSWTWGSL
TLSPSQSSNL GVLELPRVHV KDEGEFTCRA QNPLGSQHIS LSLSLQNEYT GKMRPISGVT
LGAFGGAGAT ALVFLYFCII FVVVRSCRKK SARPAVGVGD TGMEDANAVR GSASQGPLIE
SPADDSPPHH APPALATPSP EEGEIQYASL SFHKARPQYP QEQEAIGYEY SEINIPK
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details