ul_5577----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name BDKRB2( Description: bradykinin receptor B2. )
Synonyms B2R; BK-2; BK-2 receptor; BK2; BKR2; BRB2; DKFZp686O088
GO annotations GO_component: integral to plasma membrane [PMID 7916737]; plasma membrane [PMID 10653985]
GO_function:bradykinin receptor activity [PMID 8302267]; phosphoinositide phospholipase C activity [PMID 8302267]; receptor activity; rhodopsin-like receptor activity
GO_process: circulation [PMID 7835885]; elevation of cytosolic calcium ion concentration [PMID 10653985]; G-protein coupled receptor protein signaling pathway [PMID 1314587]; inflammatory response; sensory perception; smooth muscle contraction; transmembrane receptor protein tyrosine kinase signaling pathway [PMID 10653985]
RefSeq accession NP_000614
SwissProt accession P30411
Sequence:(RefSeq accession:NP_000614; substrate region highlighted if known)
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MFSPWKISMF LSVREDSVPT TASFSADMLN VTLQGPTLNG TFAQSKCPQV EWLGWLNTIQ
PPFLWVLFVL ATLENIFVLS VFCLHKSSCT VAEIYLGNLA AADLILACGL PFWAITISNN
FDWLFGETLC RVVNAIISMN LYSSICFLML VSIDRYLALV KTMSMGRMRG VRWAKLYSLV
IWGCTLLLSS PMLVFRTMKE YSDEGHNVTA CVISYPSLIW EVFTNMLLNV VGFLLPLSVI
TFCTMQIMQV LRNNEMQKFK EIQTERRATV LVLVVLLLFI ICWLPFQIST FLDTLHRLGI
LSSCQDERII DVITQIASFM AYSNSCLNPL VYVIVGKRFR KKSWEVYQGV CQKGGCRSEP
IQMENSMGTL RTSISVERQI HKLQDWAGSR Q
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details