ul_5592----
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PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name PRLR( Description: prolactin receptor. )
Synonyms hPRLrI
GO annotations GO_component: cell surface [PMID 10585417]; integral to membrane; membrane
GO_function:ornithine decarboxylase activator activity; prolactin receptor activity [PMID 10585417]; protein binding [PMID 15618286]; protein homodimerization activity [PMID 10585417]; receptor activity
GO_process: anti-apoptosis [PMID 10585417]; cell surface receptor linked signal transduction [PMID 10585417]; embryo implantation [PMID 9009200]; lactation [PMID 10585417]; steroid biosynthesis [PMID 10585417]; T cell activation [PMID 10585417]; transmembrane receptor protein tyrosine kinase activation (dimerization) [PMID 10585417]; tyrosine phosphorylation of JAK2 protein [PMID 10585417]
RefSeq accession NP_000940
SwissProt accession P16471
Sequence:(RefSeq accession:NP_000940; substrate region highlighted if known)
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MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY
SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD
VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW
EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS
VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD
FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL
SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ
PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE
SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP
ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS
KCRLQLGGLD YLDPACFTHS FH
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details