ul_5602----
Record details: Hide
PPBD protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
Substrate protein
Gene name F2R( Description: coagulation factor II (thrombin) receptor. )
Synonyms CF2R; Coagulation factor II receptor; HTR; PAR-1; PAR1; TR; Thrombin receptor
GO annotations GO_component: Golgi apparatus [PMID 7961693]; integral to plasma membrane [PMID 1672265]; plasma membrane [PMID 9038223]
GO_function:receptor activity; receptor binding [PMID 1672265]; rhodopsin-like receptor activity; thrombin receptor activity [PMID 9038223]
GO_process: apoptosis [PMID 10692450]; blood coagulation [PMID 9038223]; caspase activation [PMID 10692450]; cell motility [PMID 9701242]; G-protein coupled receptor protein signaling pathway; morphogenesis [PMID 9701242]; positive regulation of I-kappaB kinase/NF-kappaB cascade [PMID 12761501]; regulation of progression through cell cycle [PMID 10692450]; response to wounding [PMID 1672265]; signal transduction [PMID 1672265]; STAT protein nuclear translocation [PMID 10692450]; tyrosine phosphorylation of STAT protein [PMID 10692450]
RefSeq accession NP_001983
SwissProt accession P25116
Sequence:(RefSeq accession:NP_001983; substrate region highlighted if known)
1
61
121
181
241
301
361
421
MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE
KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN
IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA
AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLVLK
EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS
SISSCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY
KKLLT
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details