ul_5636----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name MCF2( Description: MCF.2 cell line derived transforming sequence. )
Synonyms DBL
GO annotations GO_component: cytoskeleton [PMID 3056717]; cytosol [PMID 3281159]; intracellular; membrane fraction [PMID 3281159]
GO_function:Rho guanyl-nucleotide exchange factor activity
GO_process: intracellular signaling cascade; regulation of Rho protein signal transduction
RefSeq accession NP_005360
SwissProt accession P10911
Sequence:(RefSeq accession:NP_005360; substrate region highlighted if known)
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MAEANPRRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFWFSQE DFMPKLPVVM
LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA
ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHR
QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ
QAELADVTGT IAQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC
NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ
KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG
FRNLADKHVR PIQFVVPTPE NLVTSGTPFF SSKQGKKTWR QNQSNLKIEV VPDCQEKRSS
GPSSSLDNGN SLDVLKNHVL NELIQTERVY VRELYTVLLG YRAEMDNPEM FDLMPPLLRN
KKDILFGNMA EIYEFHNDIF LSSLENCAHA PERVGPCFLE RKDDFQMYAK YCQNKPRSET
IWRKYSECAF FQECQRKLKH RLRLDSYLLK PVQRITKYQL LLKELLKYSK DCEGSALLKK
ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF SVWIGHKKGA TKMKDLARFK
PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP SYSFKHCWKM DEVGITEYVK GDNRKFEIWY
GEKEEVYIVQ ASNVDVKMTW LKEIRNILLK QQELLTVKKR KQQDQLTERD KFQISLQQND
EKQQGAFIST EETELEHTST VVEVCEAIAS VQAEANTVWT EASQSAEISE EPAEWSSNYF
YPTYDENEEE NRPLMRPVSE MALLY
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details