ul_5641----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name MAPK3( Description: mitogen-activated protein kinase 3. )
Synonyms EC 2.7.11.24; ERK-1; ERK1; ERT2; Extracellular signal-regulated kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; MGC20180; Microtubule-associated protein 2 kinase; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK
GO annotations GO_component:
GO_function:ATP binding; MAP kinase activity [PMID 7687743]; nucleotide binding; protein binding [PMID 9792677] [PMID 15616583]; protein serine/threonine kinase activity; transferase activity
GO_process: cell cycle; protein amino acid phosphorylation [PMID 7687743]; regulation of progression through cell cycle [PMID 7687743]
RefSeq accession NP_002737
SwissProt accession P27361
Sequence:(RefSeq accession:NP_002737; substrate region highlighted if known)
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MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE GAYGMVSSAY
DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAS TLEAMRDVYI
VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLINTTCDL
KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS
NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD
SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEP VAEEPFTFAM ELDDLPKERL
KELIFQETAR FQPGVLEAP
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details