ul_5642----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name Epor( Description: erythropoietin receptor. )
Synonyms
GO annotations GO_component: membrane
GO_function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity; transmembrane receptor activity
GO_process:
RefSeq accession NP_034279
SwissProt accession
Sequence:(RefSeq accession:NP_034279; substrate region highlighted if known)
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MDKLRVPLWP RVGPLCLLLA GAAWAPSPSL PDPKFESKAA LLASRGSEEL LCFTQRLEDL
VCFWEEAASS GMDFNYSFSY QLEGESRKSC SLHQAPTVRG SVRFWCSLPT ADTSSFVPLE
LQVTEASGSP RYHRIIHINE VVLLDAPAGL LARRAEEGSH VVLRWLPPPG APMTTHIRYE
VDVSAGNRAG GTQRVEVLEG RTECVLSNLR GGTRYTFAVR ARMAEPSFSG FWSAWSEPAS
LLTASDLDPL ILTLSLILVL ISLLLTVLAL LSHRRTLQQK IWPGIPSPES EFEGLFTTHK
GNFQLWLLQR DGCLWWSPGS SFPEDPPAHL EVLSEPRWAV TQAGDPGADD EGPLLEPVGS
EHAQDTYLVL DKWLLPRTPC SENLSGPGGS VDPVTMDEAS ETSSCPSDLA SKPRPEGTSP
SSFEYTILDP SSQLLCPRAL PPELPPTPPH LKYLYLVVSD SGISTDYSSG GSQGVHGDSS
DGPYSHPYEN SLVPDSEPLH PGYVACS
Records:
Category Evidence Reference
A Peptide library Yi T, Zhang J, Miura O, Ihle JN., Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites, [7528577]
End of Record Details